Antioxidative activity of thiophane [bis(3-(3,5-di-tret-butyl-4-hydroxyphenyl)propyl)sulfide]

The antioxidant activity, mutagenicity, and genotoxicity of bis(3-(3,5-di- tret -butyl-4-hydroxyphenyl)propyl)sulfide (thiophane) were studied using bacterial tests. The results of both an Ames test and SOS chromotest, as well as those studying the survival of E. coli cells deficient in enzymes resp...

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Veröffentlicht in:	Russian journal of bioorganic chemistry 2009-05, Vol.35 (3), p.379-384
Hauptverfasser:	Ovchinnikova, L. P., Rotskaya, U. N., Vasyunina, E. A., Sinitsina, O. I., Kandalintseva, N. V., Prosenko, A. E., Nevinskii, G. A.
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Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Life Sciences Organic Chemistry
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container_title	Russian journal of bioorganic chemistry
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creator	Ovchinnikova, L. P. Rotskaya, U. N. Vasyunina, E. A. Sinitsina, O. I. Kandalintseva, N. V. Prosenko, A. E. Nevinskii, G. A.
description	The antioxidant activity, mutagenicity, and genotoxicity of bis(3-(3,5-di- tret -butyl-4-hydroxyphenyl)propyl)sulfide (thiophane) were studied using bacterial tests. The results of both an Ames test and SOS chromotest, as well as those studying the survival of E. coli cells deficient in enzymes responsible for the repair of DNA oxidative damage, testify to the fact that thiophane is not mutagenic and genotoxic, and it protects Salmonella typhimurium cells better than the well-known antioxidant trolox.
doi_str_mv	10.1134/S1068162009030145
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subjects	Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Life Sciences Organic Chemistry
title	Antioxidative activity of thiophane [bis(3-(3,5-di-tret-butyl-4-hydroxyphenyl)propyl)sulfide]
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