Association between rs4986790 and rs4986791 Polymorphisms in TLR4 with Colorectal Cancer Risk in Iranian Population
Colorectal cancer (CRC) is one of the important leading causes of cancer-related death worldwide. Chronic inflammation has been identified as a major risk factor in CRC. Toll-like receptor 4 (TLR4) is a critical receptor and regulates inflammation. The current study was conducted to investigate the...
Gespeichert in:
| Veröffentlicht in: | Russian journal of genetics 2021-06, Vol.57 (6), p.740-744 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 744 |
|---|---|
| container_issue | 6 |
| container_start_page | 740 |
| container_title | Russian journal of genetics |
| container_volume | 57 |
| creator | Asghari, A. Nowras, T. Tavakoli, T. Fakharian, T. Razavi, F. Emadian Soltaninejad, E. Naseri, M. |
| description | Colorectal cancer (CRC) is one of the important leading causes of cancer-related death worldwide. Chronic inflammation has been identified as a major risk factor in CRC. Toll-like receptor 4 (TLR4) is a critical receptor and regulates inflammation. The current study was conducted to investigate the association between two single nucleotide polymorphisms (SNPs) (rs4986790 and rs4986791) in TLR4 gene and susceptibility to CRC. The samples including 90 CRC cases as well as 90 matched controls were obtained from South Khorasan, Iran, between 2014 and 2016. Genomic DNA was genotyped using polymerase chain reaction (PCR) method followed by PCR-restriction fragment length polymorphism (RFLP). Data were statistically analyzed based on chi-square test. Hardy–Weinberg equilibrium was maintained in the control group. In conclusion, there were no significant associations between TLR4 mutations and CRC risk within the studied population. However, to confirm these results, more investigations are necessary in a larger population in Iran and other countries. |
| doi_str_mv | 10.1134/S1022795421060028 |
| format | Article |
| fullrecord | <record><control><sourceid>crossref_sprin</sourceid><recordid>TN_cdi_crossref_primary_10_1134_S1022795421060028</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1134_S1022795421060028</sourcerecordid><originalsourceid>FETCH-LOGICAL-c218t-d264451dd0fbb4e747b780cc474d1bef8ac90eb6d96e96582bb737e1acb0b2df3</originalsourceid><addsrcrecordid>eNp9kN1KAzEQhYMoWKsP4F1eYHWSTZPsZVn8KRSUWq-X_K1N3SYl2VL69m6teCN4NTOc880MB6FbAneElOz-jQClopowSoADUHmGRoSDLMqSV-dDP8jFUb9EVzmvAQgAL0coT3OOxqvex4C16_fOBZwyqyQXFWAV7O9E8GvsDpuYtiufNxn7gJfzBcN7369wHbuYnOlVh2sVjEt44fPn0TNLKngVBni7677vXKOLVnXZ3fzUMXp_fFjWz8X85WlWT-eFoUT2haWcsQmxFlqtmRNMaCHBGCaYJdq1UpkKnOa24q7iE0m1FqVwRBkNmtq2HCNy2mtSzDm5ttkmv1Hp0BBojqk1f1IbGHpi8uANHy4167hLYXjzH-gLMshuYA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Association between rs4986790 and rs4986791 Polymorphisms in TLR4 with Colorectal Cancer Risk in Iranian Population</title><source>SpringerLink Journals</source><creator>Asghari, A. ; Nowras, T. ; Tavakoli, T. ; Fakharian, T. ; Razavi, F. Emadian ; Soltaninejad, E. ; Naseri, M.</creator><creatorcontrib>Asghari, A. ; Nowras, T. ; Tavakoli, T. ; Fakharian, T. ; Razavi, F. Emadian ; Soltaninejad, E. ; Naseri, M.</creatorcontrib><description>Colorectal cancer (CRC) is one of the important leading causes of cancer-related death worldwide. Chronic inflammation has been identified as a major risk factor in CRC. Toll-like receptor 4 (TLR4) is a critical receptor and regulates inflammation. The current study was conducted to investigate the association between two single nucleotide polymorphisms (SNPs) (rs4986790 and rs4986791) in TLR4 gene and susceptibility to CRC. The samples including 90 CRC cases as well as 90 matched controls were obtained from South Khorasan, Iran, between 2014 and 2016. Genomic DNA was genotyped using polymerase chain reaction (PCR) method followed by PCR-restriction fragment length polymorphism (RFLP). Data were statistically analyzed based on chi-square test. Hardy–Weinberg equilibrium was maintained in the control group. In conclusion, there were no significant associations between TLR4 mutations and CRC risk within the studied population. However, to confirm these results, more investigations are necessary in a larger population in Iran and other countries.</description><identifier>ISSN: 1022-7954</identifier><identifier>EISSN: 1608-3369</identifier><identifier>DOI: 10.1134/S1022795421060028</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Animal Genetics and Genomics ; Biomedical and Life Sciences ; Biomedicine ; Human Genetics ; Microbial Genetics and Genomics</subject><ispartof>Russian journal of genetics, 2021-06, Vol.57 (6), p.740-744</ispartof><rights>Pleiades Publishing, Inc. 2021. ISSN 1022-7954, Russian Journal of Genetics, 2021, Vol. 57, No. 6, pp. 740–744. © Pleiades Publishing, Inc., 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c218t-d264451dd0fbb4e747b780cc474d1bef8ac90eb6d96e96582bb737e1acb0b2df3</citedby><cites>FETCH-LOGICAL-c218t-d264451dd0fbb4e747b780cc474d1bef8ac90eb6d96e96582bb737e1acb0b2df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1022795421060028$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1022795421060028$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>Asghari, A.</creatorcontrib><creatorcontrib>Nowras, T.</creatorcontrib><creatorcontrib>Tavakoli, T.</creatorcontrib><creatorcontrib>Fakharian, T.</creatorcontrib><creatorcontrib>Razavi, F. Emadian</creatorcontrib><creatorcontrib>Soltaninejad, E.</creatorcontrib><creatorcontrib>Naseri, M.</creatorcontrib><title>Association between rs4986790 and rs4986791 Polymorphisms in TLR4 with Colorectal Cancer Risk in Iranian Population</title><title>Russian journal of genetics</title><addtitle>Russ J Genet</addtitle><description>Colorectal cancer (CRC) is one of the important leading causes of cancer-related death worldwide. Chronic inflammation has been identified as a major risk factor in CRC. Toll-like receptor 4 (TLR4) is a critical receptor and regulates inflammation. The current study was conducted to investigate the association between two single nucleotide polymorphisms (SNPs) (rs4986790 and rs4986791) in TLR4 gene and susceptibility to CRC. The samples including 90 CRC cases as well as 90 matched controls were obtained from South Khorasan, Iran, between 2014 and 2016. Genomic DNA was genotyped using polymerase chain reaction (PCR) method followed by PCR-restriction fragment length polymorphism (RFLP). Data were statistically analyzed based on chi-square test. Hardy–Weinberg equilibrium was maintained in the control group. In conclusion, there were no significant associations between TLR4 mutations and CRC risk within the studied population. However, to confirm these results, more investigations are necessary in a larger population in Iran and other countries.</description><subject>Animal Genetics and Genomics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Human Genetics</subject><subject>Microbial Genetics and Genomics</subject><issn>1022-7954</issn><issn>1608-3369</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kN1KAzEQhYMoWKsP4F1eYHWSTZPsZVn8KRSUWq-X_K1N3SYl2VL69m6teCN4NTOc880MB6FbAneElOz-jQClopowSoADUHmGRoSDLMqSV-dDP8jFUb9EVzmvAQgAL0coT3OOxqvex4C16_fOBZwyqyQXFWAV7O9E8GvsDpuYtiufNxn7gJfzBcN7369wHbuYnOlVh2sVjEt44fPn0TNLKngVBni7677vXKOLVnXZ3fzUMXp_fFjWz8X85WlWT-eFoUT2haWcsQmxFlqtmRNMaCHBGCaYJdq1UpkKnOa24q7iE0m1FqVwRBkNmtq2HCNy2mtSzDm5ttkmv1Hp0BBojqk1f1IbGHpi8uANHy4167hLYXjzH-gLMshuYA</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Asghari, A.</creator><creator>Nowras, T.</creator><creator>Tavakoli, T.</creator><creator>Fakharian, T.</creator><creator>Razavi, F. Emadian</creator><creator>Soltaninejad, E.</creator><creator>Naseri, M.</creator><general>Pleiades Publishing</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20210601</creationdate><title>Association between rs4986790 and rs4986791 Polymorphisms in TLR4 with Colorectal Cancer Risk in Iranian Population</title><author>Asghari, A. ; Nowras, T. ; Tavakoli, T. ; Fakharian, T. ; Razavi, F. Emadian ; Soltaninejad, E. ; Naseri, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c218t-d264451dd0fbb4e747b780cc474d1bef8ac90eb6d96e96582bb737e1acb0b2df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animal Genetics and Genomics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Human Genetics</topic><topic>Microbial Genetics and Genomics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asghari, A.</creatorcontrib><creatorcontrib>Nowras, T.</creatorcontrib><creatorcontrib>Tavakoli, T.</creatorcontrib><creatorcontrib>Fakharian, T.</creatorcontrib><creatorcontrib>Razavi, F. Emadian</creatorcontrib><creatorcontrib>Soltaninejad, E.</creatorcontrib><creatorcontrib>Naseri, M.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asghari, A.</au><au>Nowras, T.</au><au>Tavakoli, T.</au><au>Fakharian, T.</au><au>Razavi, F. Emadian</au><au>Soltaninejad, E.</au><au>Naseri, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between rs4986790 and rs4986791 Polymorphisms in TLR4 with Colorectal Cancer Risk in Iranian Population</atitle><jtitle>Russian journal of genetics</jtitle><stitle>Russ J Genet</stitle><date>2021-06-01</date><risdate>2021</risdate><volume>57</volume><issue>6</issue><spage>740</spage><epage>744</epage><pages>740-744</pages><issn>1022-7954</issn><eissn>1608-3369</eissn><abstract>Colorectal cancer (CRC) is one of the important leading causes of cancer-related death worldwide. Chronic inflammation has been identified as a major risk factor in CRC. Toll-like receptor 4 (TLR4) is a critical receptor and regulates inflammation. The current study was conducted to investigate the association between two single nucleotide polymorphisms (SNPs) (rs4986790 and rs4986791) in TLR4 gene and susceptibility to CRC. The samples including 90 CRC cases as well as 90 matched controls were obtained from South Khorasan, Iran, between 2014 and 2016. Genomic DNA was genotyped using polymerase chain reaction (PCR) method followed by PCR-restriction fragment length polymorphism (RFLP). Data were statistically analyzed based on chi-square test. Hardy–Weinberg equilibrium was maintained in the control group. In conclusion, there were no significant associations between TLR4 mutations and CRC risk within the studied population. However, to confirm these results, more investigations are necessary in a larger population in Iran and other countries.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1022795421060028</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1022-7954 |
| ispartof | Russian journal of genetics, 2021-06, Vol.57 (6), p.740-744 |
| issn | 1022-7954 1608-3369 |
| language | eng |
| recordid | cdi_crossref_primary_10_1134_S1022795421060028 |
| source | SpringerLink Journals |
| subjects | Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Human Genetics Microbial Genetics and Genomics |
| title | Association between rs4986790 and rs4986791 Polymorphisms in TLR4 with Colorectal Cancer Risk in Iranian Population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T02%3A32%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref_sprin&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20rs4986790%20and%20rs4986791%20Polymorphisms%20in%20TLR4%20with%20Colorectal%20Cancer%20Risk%20in%20Iranian%20Population&rft.jtitle=Russian%20journal%20of%20genetics&rft.au=Asghari,%20A.&rft.date=2021-06-01&rft.volume=57&rft.issue=6&rft.spage=740&rft.epage=744&rft.pages=740-744&rft.issn=1022-7954&rft.eissn=1608-3369&rft_id=info:doi/10.1134/S1022795421060028&rft_dat=%3Ccrossref_sprin%3E10_1134_S1022795421060028%3C/crossref_sprin%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |