Association between Allelic Variants of the Genes Involved in Glucocorticoids Metabolism and Asthma
Bronchial asthma (BA) is a common severe and disabling multifactorial disease. Up to 50–60% of differences in sensitivity to therapy in patients with BA is due to genetic variability. We studied polymorphic variants of four genes involved in the metabolism of glucocorticosteroids in patients with as...
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Veröffentlicht in: | Russian journal of genetics 2019-12, Vol.55 (12), p.1520-1527 |
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Sprache: | eng |
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Zusammenfassung: | Bronchial asthma (BA) is a common severe and disabling multifactorial disease. Up to 50–60% of differences in sensitivity to therapy in patients with BA is due to genetic variability. We studied polymorphic variants of four genes involved in the metabolism of glucocorticosteroids in patients with asthma and healthy individuals of Russian, Tatar and Bashkir ethnic origin: rs37973 of the glucocorticoid-induced transcript 1 gene (
GLCCI1
), rs2305089 of the transcription factor T gene (
TBXT
), rs10044254 of the F-box and leucine-rich repeat protein gene (
FBXL7
), rs11123610 of the allantoicase gene (
ALLC
). It has been established that, in Tatars, the rs37973
G
allele of the
GLCCI1
gene is a marker of an increased risk of developing BA with an uncontrolled course, while a decrease in spirography is observed in patients with the rs37973
AG
and rs37973
GG
genotypes of the
GLCCI1
gene compared with children with rs37973
AA
genotypes. In Bashkirs, a marker of an increased risk of developing the disease is the rs2305089
T
allele of the
TBXT
gene polymorphic variant. |
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ISSN: | 1022-7954 1608-3369 |
DOI: | 10.1134/S1022795419120044 |