Association Analysis of Polymorphic Gene Variants in the JAK/STAT Signaling Pathway with Aging and Longevity
The aim of this study was to investigate the associations between the polymorphic loci in the JAK/STAT signaling pathway and the aging processes and longevity in the populations of ethnic Tatars. For this aim, we analyzed the age dynamics of genotype frequencies of the JAK1 (32454C>T, rs310216),...
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| Veröffentlicht in: | Russian journal of genetics 2019-06, Vol.55 (6), p.728-737 |
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| creator | Erdman, V. V. Nasibullin, T. R. Tuktarova, I. A. Somova, R. Sh Mustafina, O. E. |
| description | The aim of this study was to investigate the associations between the polymorphic loci in the JAK/STAT signaling pathway and the aging processes and longevity in the populations of ethnic Tatars. For this aim, we analyzed the age dynamics of genotype frequencies of the
JAK1
(32454C>T, rs310216),
JAK3
(14385C>T, rs3212780),
STAT1
(14228A>C, rs12693591),
STAT3
(19006G>C, rs2293152), and
STAT5A
(1985T>C, rs9889323) genes. Using logistic regression analysis, we discovered the association of these polymorphic loci with advanced age. In the general study group, the probability of the
JAK1
*C/*Т genotype was higher among persons of advanced age (69–80 years old,
p
= 0.031, OR = 1.070). In turn, the chance to reach advanced age was lower among the carriers of the
JAK1
*Т/*Т (58–82 years old,
p
= 0.014, OR = 0.958) and
STAT5A
*T/*T (46–109 years old,
p
< 0.001, OR = 0.979) genotypes. The probability of attaining longevity was higher among men with the
STAT3
*С/*С genotype (25–98 years old,
p
= 0.027, OR = 1.016) and was lower among men with the
STAT3
*G/*С genotype (73–98 years old,
p
= 0.044, OR = 0.950). In the group of women, the probability to reach 80 years of age and over was higher among carriers of the
JAK3
*Т/*С (48–81 years old,
p
= 0.046, OR = 1.024),
STAT1
*С/*A (61–88 years old,
p
= 0.041, OR = 1.035), and
STAT5A
*T/*C (46–82 years old,
p
< 0.0001, OR = 1.044) genotypes. In turn, among middle age women with the
STAT1
*С/*С genotype, the probability to attain longevity was lower (55–109 years old,
p
= 0.013, OR = 0.980). |
| doi_str_mv | 10.1134/S1022795419050077 |
| format | Article |
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JAK1
(32454C>T, rs310216),
JAK3
(14385C>T, rs3212780),
STAT1
(14228A>C, rs12693591),
STAT3
(19006G>C, rs2293152), and
STAT5A
(1985T>C, rs9889323) genes. Using logistic regression analysis, we discovered the association of these polymorphic loci with advanced age. In the general study group, the probability of the
JAK1
*C/*Т genotype was higher among persons of advanced age (69–80 years old,
p
= 0.031, OR = 1.070). In turn, the chance to reach advanced age was lower among the carriers of the
JAK1
*Т/*Т (58–82 years old,
p
= 0.014, OR = 0.958) and
STAT5A
*T/*T (46–109 years old,
p
< 0.001, OR = 0.979) genotypes. The probability of attaining longevity was higher among men with the
STAT3
*С/*С genotype (25–98 years old,
p
= 0.027, OR = 1.016) and was lower among men with the
STAT3
*G/*С genotype (73–98 years old,
p
= 0.044, OR = 0.950). In the group of women, the probability to reach 80 years of age and over was higher among carriers of the
JAK3
*Т/*С (48–81 years old,
p
= 0.046, OR = 1.024),
STAT1
*С/*A (61–88 years old,
p
= 0.041, OR = 1.035), and
STAT5A
*T/*C (46–82 years old,
p
< 0.0001, OR = 1.044) genotypes. In turn, among middle age women with the
STAT1
*С/*С genotype, the probability to attain longevity was lower (55–109 years old,
p
= 0.013, OR = 0.980).</description><identifier>ISSN: 1022-7954</identifier><identifier>EISSN: 1608-3369</identifier><identifier>DOI: 10.1134/S1022795419050077</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Animal Genetics and Genomics ; Biomedical and Life Sciences ; Biomedicine ; Human Genetics ; Microbial Genetics and Genomics</subject><ispartof>Russian journal of genetics, 2019-06, Vol.55 (6), p.728-737</ispartof><rights>Pleiades Publishing, Inc. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c288t-da33fbb7c0cd8353318af90a06633f95e52d5a4513379752b25947292e276bf3</citedby><cites>FETCH-LOGICAL-c288t-da33fbb7c0cd8353318af90a06633f95e52d5a4513379752b25947292e276bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1022795419050077$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1022795419050077$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Erdman, V. V.</creatorcontrib><creatorcontrib>Nasibullin, T. R.</creatorcontrib><creatorcontrib>Tuktarova, I. A.</creatorcontrib><creatorcontrib>Somova, R. Sh</creatorcontrib><creatorcontrib>Mustafina, O. E.</creatorcontrib><title>Association Analysis of Polymorphic Gene Variants in the JAK/STAT Signaling Pathway with Aging and Longevity</title><title>Russian journal of genetics</title><addtitle>Russ J Genet</addtitle><description>The aim of this study was to investigate the associations between the polymorphic loci in the JAK/STAT signaling pathway and the aging processes and longevity in the populations of ethnic Tatars. For this aim, we analyzed the age dynamics of genotype frequencies of the
JAK1
(32454C>T, rs310216),
JAK3
(14385C>T, rs3212780),
STAT1
(14228A>C, rs12693591),
STAT3
(19006G>C, rs2293152), and
STAT5A
(1985T>C, rs9889323) genes. Using logistic regression analysis, we discovered the association of these polymorphic loci with advanced age. In the general study group, the probability of the
JAK1
*C/*Т genotype was higher among persons of advanced age (69–80 years old,
p
= 0.031, OR = 1.070). In turn, the chance to reach advanced age was lower among the carriers of the
JAK1
*Т/*Т (58–82 years old,
p
= 0.014, OR = 0.958) and
STAT5A
*T/*T (46–109 years old,
p
< 0.001, OR = 0.979) genotypes. The probability of attaining longevity was higher among men with the
STAT3
*С/*С genotype (25–98 years old,
p
= 0.027, OR = 1.016) and was lower among men with the
STAT3
*G/*С genotype (73–98 years old,
p
= 0.044, OR = 0.950). In the group of women, the probability to reach 80 years of age and over was higher among carriers of the
JAK3
*Т/*С (48–81 years old,
p
= 0.046, OR = 1.024),
STAT1
*С/*A (61–88 years old,
p
= 0.041, OR = 1.035), and
STAT5A
*T/*C (46–82 years old,
p
< 0.0001, OR = 1.044) genotypes. In turn, among middle age women with the
STAT1
*С/*С genotype, the probability to attain longevity was lower (55–109 years old,
p
= 0.013, OR = 0.980).</description><subject>Animal Genetics and Genomics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Human Genetics</subject><subject>Microbial Genetics and Genomics</subject><issn>1022-7954</issn><issn>1608-3369</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kN9KwzAUxoMoOKcP4F1eoC5_mqa5LEPndOBgxduStmmb0SUjiY6-vRnzTvDqHM53fofvfAA8YvSEMU0XO4wI4YKlWCCGEOdXYIYzlCeUZuI69lFOzvotuPN-jxBGKKMzMBbe20bLoK2BhZHj5LWHtoNbO04H646DbuBKGQU_pdPSBA-1gWFQ8K14X-zKooQ73UdOmx5uZRhOcoInHQZY9OeRNC3cWNOrbx2me3DTydGrh986B-XLc7l8TTYfq_Wy2CQNyfOQtJLSrq55g5o2p4xSnMtOIImyLAqCKUZaJlOGKeWCM1ITJlJOBFGEZ3VH5wBfzjbOeu9UVx2dPkg3VRhV57SqP2lFhlwYH3ejXVft7ZeLf_l_oB9emWt-</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Erdman, V. V.</creator><creator>Nasibullin, T. R.</creator><creator>Tuktarova, I. A.</creator><creator>Somova, R. Sh</creator><creator>Mustafina, O. E.</creator><general>Pleiades Publishing</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20190601</creationdate><title>Association Analysis of Polymorphic Gene Variants in the JAK/STAT Signaling Pathway with Aging and Longevity</title><author>Erdman, V. V. ; Nasibullin, T. R. ; Tuktarova, I. A. ; Somova, R. Sh ; Mustafina, O. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c288t-da33fbb7c0cd8353318af90a06633f95e52d5a4513379752b25947292e276bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal Genetics and Genomics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Human Genetics</topic><topic>Microbial Genetics and Genomics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erdman, V. V.</creatorcontrib><creatorcontrib>Nasibullin, T. R.</creatorcontrib><creatorcontrib>Tuktarova, I. A.</creatorcontrib><creatorcontrib>Somova, R. Sh</creatorcontrib><creatorcontrib>Mustafina, O. E.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erdman, V. V.</au><au>Nasibullin, T. R.</au><au>Tuktarova, I. A.</au><au>Somova, R. Sh</au><au>Mustafina, O. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Analysis of Polymorphic Gene Variants in the JAK/STAT Signaling Pathway with Aging and Longevity</atitle><jtitle>Russian journal of genetics</jtitle><stitle>Russ J Genet</stitle><date>2019-06-01</date><risdate>2019</risdate><volume>55</volume><issue>6</issue><spage>728</spage><epage>737</epage><pages>728-737</pages><issn>1022-7954</issn><eissn>1608-3369</eissn><abstract>The aim of this study was to investigate the associations between the polymorphic loci in the JAK/STAT signaling pathway and the aging processes and longevity in the populations of ethnic Tatars. For this aim, we analyzed the age dynamics of genotype frequencies of the
JAK1
(32454C>T, rs310216),
JAK3
(14385C>T, rs3212780),
STAT1
(14228A>C, rs12693591),
STAT3
(19006G>C, rs2293152), and
STAT5A
(1985T>C, rs9889323) genes. Using logistic regression analysis, we discovered the association of these polymorphic loci with advanced age. In the general study group, the probability of the
JAK1
*C/*Т genotype was higher among persons of advanced age (69–80 years old,
p
= 0.031, OR = 1.070). In turn, the chance to reach advanced age was lower among the carriers of the
JAK1
*Т/*Т (58–82 years old,
p
= 0.014, OR = 0.958) and
STAT5A
*T/*T (46–109 years old,
p
< 0.001, OR = 0.979) genotypes. The probability of attaining longevity was higher among men with the
STAT3
*С/*С genotype (25–98 years old,
p
= 0.027, OR = 1.016) and was lower among men with the
STAT3
*G/*С genotype (73–98 years old,
p
= 0.044, OR = 0.950). In the group of women, the probability to reach 80 years of age and over was higher among carriers of the
JAK3
*Т/*С (48–81 years old,
p
= 0.046, OR = 1.024),
STAT1
*С/*A (61–88 years old,
p
= 0.041, OR = 1.035), and
STAT5A
*T/*C (46–82 years old,
p
< 0.0001, OR = 1.044) genotypes. In turn, among middle age women with the
STAT1
*С/*С genotype, the probability to attain longevity was lower (55–109 years old,
p
= 0.013, OR = 0.980).</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1022795419050077</doi><tpages>10</tpages></addata></record> |
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| issn | 1022-7954 1608-3369 |
| language | eng |
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| source | SpringerNature Journals |
| subjects | Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Human Genetics Microbial Genetics and Genomics |
| title | Association Analysis of Polymorphic Gene Variants in the JAK/STAT Signaling Pathway with Aging and Longevity |
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