siRNAs with high specificity to a target: A systematic design by the CRM algorithm

The “off-target” silencing effect hinders the development of siRNA-based therapeutic and research applications. A common solution to this problem is an employment of BLAST, which may miss significant alignments, or an exhaustive Smith-Waterman algorithm, which is very time-consuming. A Comprehensive...

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Veröffentlicht in:	Molecular biology (New York) 2008-01, Vol.42 (1), p.146-152
Hauptverfasser:	Alsheddi, T., Vasin, L., Meduri, R., Randhawa, M., Glazko, G., Baranova, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Human Genetics Life Sciences Mathematical and System Biology
Online-Zugang:	Volltext
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