Association of polymorphisms of immune response modifier genes with celiac disease and its clinical forms in the Tomsk population
Association of different alleles of immune response modifier genes IL1B (+3953A1/A2), IL1RN (VNTR), IL4 (3′-UTR G/C), IL4RA (I50V), IL12B (1188A/C), and VDR (F/f and B/b) with celiac disease (CD) and its clinical forms was investigated in a family cohort of CD patients from the Tomsk region (N = 139...
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| Veröffentlicht in: | Molecular biology (New York) 2008-01, Vol.42 (1), p.37-43 |
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| creator | Rudko, A. A Kondratieva, E. I Yankina, G. N Loshkova, E. V Puzyrev, V. P |
| description | Association of different alleles of immune response modifier genes IL1B (+3953A1/A2), IL1RN (VNTR), IL4 (3′-UTR G/C), IL4RA (I50V), IL12B (1188A/C), and VDR (F/f and B/b) with celiac disease (CD) and its clinical forms was investigated in a family cohort of CD patients from the Tomsk region (N = 139, including 49 probands, i.e., affected children). The control group comprised 129 healthy Russians from Tomsk. A case-control study did not associate any of the polymorphic markers with CD. In a family-based study, the 3′-UTR G/C polymorphism of IL4 was associated with CD (P = 0.024), its atypical form (P = 0.001), and its complications such as osteopenia (P = 0.039) and autoimmune thyroiditis (P = 0.042). IL4RA and VDR polymorphisms I50V and F/f were associated with the typical form of CD (P = 0.001 and P = 0.009, respectively). In general, associations with CD phenotypes were shown primarily for polymorphisms of the genes involved in Th2 immunity. |
| doi_str_mv | 10.1134/S0026893308010056 |
| format | Article |
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IL4RA and VDR polymorphisms I50V and F/f were associated with the typical form of CD (P = 0.001 and P = 0.009, respectively). In general, associations with CD phenotypes were shown primarily for polymorphisms of the genes involved in Th2 immunity.</description><identifier>ISSN: 0026-8933</identifier><identifier>EISSN: 1608-3245</identifier><identifier>DOI: 10.1134/S0026893308010056</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : SP MAIK Nauka/Interperiodica</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Genomics. Transcriptomics. 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In a family-based study, the 3′-UTR G/C polymorphism of IL4 was associated with CD (P = 0.024), its atypical form (P = 0.001), and its complications such as osteopenia (P = 0.039) and autoimmune thyroiditis (P = 0.042). IL4RA and VDR polymorphisms I50V and F/f were associated with the typical form of CD (P = 0.001 and P = 0.009, respectively). In general, associations with CD phenotypes were shown primarily for polymorphisms of the genes involved in Th2 immunity.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Genomics. Transcriptomics. 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Proteomics</topic><topic>Human Genetics</topic><topic>Life Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rudko, A. A</creatorcontrib><creatorcontrib>Kondratieva, E. I</creatorcontrib><creatorcontrib>Yankina, G. N</creatorcontrib><creatorcontrib>Loshkova, E. V</creatorcontrib><creatorcontrib>Puzyrev, V. P</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><jtitle>Molecular biology (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rudko, A. A</au><au>Kondratieva, E. I</au><au>Yankina, G. N</au><au>Loshkova, E. V</au><au>Puzyrev, V. 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In a family-based study, the 3′-UTR G/C polymorphism of IL4 was associated with CD (P = 0.024), its atypical form (P = 0.001), and its complications such as osteopenia (P = 0.039) and autoimmune thyroiditis (P = 0.042). IL4RA and VDR polymorphisms I50V and F/f were associated with the typical form of CD (P = 0.001 and P = 0.009, respectively). In general, associations with CD phenotypes were shown primarily for polymorphisms of the genes involved in Th2 immunity.</abstract><cop>Dordrecht</cop><pub>Dordrecht : SP MAIK Nauka/Interperiodica</pub><doi>10.1134/S0026893308010056</doi><tpages>7</tpages></addata></record> |
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| subjects | Biochemistry Biomedical and Life Sciences Genomics. Transcriptomics. Proteomics Human Genetics Life Sciences |
| title | Association of polymorphisms of immune response modifier genes with celiac disease and its clinical forms in the Tomsk population |
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