Deuterium and tritium incorporation into 5-Oxo-Pro-His-Pro-NH2 by isotope exchange

Deuterium and tritium incorporation into 5-Oxo-Pro-His-Pro-NH2 by isotope exchange

When metal catalysts of the same group are used, the nature of the inorganic support with the surface-deposited peptide becomes the crucial factor determining the yield and hydrogen isotope content of 5-oxo-Pro-His-Pro-NH 2 . The label distribution in the amino acid residues of 5-oxo-Pro-His-Pro-NH...

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Veröffentlicht in:Doklady. Chemistry 2015-10, Vol.464 (2), p.236-241
Hauptverfasser: Shevchenko, V. P., Nagaev, I. Yu, Petunov, S. G., Shevchenko, K. V., Radilov, A. S., Myasoedov, N. F.
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Chemistry/Food Science
Industrial Chemistry/Chemical Engineering
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container_end_page 241
container_issue 2
container_start_page 236
container_title Doklady. Chemistry
container_volume 464
creator Shevchenko, V. P.
Nagaev, I. Yu
Petunov, S. G.
Shevchenko, K. V.
Radilov, A. S.
Myasoedov, N. F.
description When metal catalysts of the same group are used, the nature of the inorganic support with the surface-deposited peptide becomes the crucial factor determining the yield and hydrogen isotope content of 5-oxo-Pro-His-Pro-NH 2 . The label distribution in the amino acid residues of 5-oxo-Pro-His-Pro-NH 2 was found. The label was shown to be mainly incorporated in His. The synthesis in the presence of deuterium or tritium afforded labeled specimens containing about 3 deuterium atoms or 2.5 tritium atoms (about 70 Ci/mmol) per peptide molecule.
doi_str_mv 10.1134/S001250081510002X
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Industrial Chemistry/Chemical Engineering
title Deuterium and tritium incorporation into 5-Oxo-Pro-His-Pro-NH2 by isotope exchange
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