Structure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone α

Mutations in thyroid hormone receptor α (TRα), a ligand-inducible transcription factor, cause resistance to thyroid hormone α (RTHα). This disorder is characterized by tissue-specific hormone refractoriness and hypothyroidism due to the inhibition of target gene expression by mutant TRα-corepressor...

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Veröffentlicht in:	Molecular and cellular biology 2022-02, Vol.42 (2), p.e0036321-e0036321
Hauptverfasser:	Romartinez-Alonso, Beatriz, Agostini, Maura, Jones, Heulyn, McLellan, Jayde, Sood, D. Eilidh, Tomkinson, Nicholas, Marelli, Federica, Gentile, Ilaria, Visser, W. Edward, Schoenmakers, Erik, Fairall, Louise, Privalsky, Martin, Moran, Carla, Persani, Luca, Chatterjee, Krishna, Schwabe, John W. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Co-Repressor Proteins - genetics Gene Expression - physiology Genetic Predisposition to Disease - genetics Humans Molecular and Cellular Biology Mutation - genetics Phenotype Receptors, Thyroid Hormone - genetics Research Article resistance to thyroid hormone Spotlight Spotlight Selection thyroid hormone receptor α Thyroid Hormone Receptors alpha - metabolism Thyroid Hormones - metabolism transcriptional repression Triiodothyronine - genetics
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