Genetic Association Reveals Protection against Recurrence of Clostridium difficile Infection with Bezlotoxumab Treatment

Bezlotoxumab is a human monoclonal antibody against Clostridium difficile toxin B, indicated to prevent recurrence of C. difficile infection (rCDI) in high-risk adults receiving antibacterial treatment for CDI. An exploratory genome-wide association study investigated whether human genetic variation...

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Veröffentlicht in:	mSphere 2020-05, Vol.5 (3), Article 00232
Hauptverfasser:	Shen, Judong, Mehrotra, Devan, Dorr, Mary Beth, Zeng, Zhen, Li, Junhua, Xu, Xun, Nickle, David, Holzinger, Emily R., Chhibber, Aparna, Wilcox, Mark H., Blanchard, Rebecca L., Shaw, Peter M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Alleles Antibiotics Antigens Chromosome 6 Clinical trials Clostridium difficile Confidence intervals DQA1 protein Drb1 protein Gene expression Genetic diversity Genetic variability Genome-wide association studies Genomes Genotype & phenotype Histocompatibility antigen HLA Host-Microbe Biology Infections Inflammatory bowel disease Life Sciences & Biomedicine Major histocompatibility complex Microbiology Monoclonal antibodies Morbidity Mortality Polymorphism Recurrent infection Science & Technology Single-nucleotide polymorphism Toxin B
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