Miro-1 Links Mitochondria and Microtubule Dynein Motors To Control Lymphocyte Migration and Polarity

The recruitment of leukocytes to sites of inflammation is crucial for a functional immune response. In the present work, we explored the role of mitochondria in lymphocyte adhesion, polarity, and migration. We show that during adhesion to the activated endothelium under physiological flow conditions...

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Veröffentlicht in:	Molecular and cellular biology 2014-04, Vol.34 (8), p.1412-1426
Hauptverfasser:	Morlino, Giulia, Barreiro, Olga, Baixauli, Francesc, Robles-Valero, Javier, González-Granado, José M., Villa-Bellosta, Ricardo, Cuenca, Jesús, Sánchez-Sorzano, Carlos O., Veiga, Esteban, Martín-Cófreces, Noa B., Sánchez-Madrid, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	actin adhesion Cell Movement - physiology Cell Polarity - immunology Cell Polarity - physiology Chemokine CXCL12 - metabolism chemokines Cytoskeleton - metabolism dynein ATPase Dyneins - genetics Dyneins - metabolism endothelium Gene Silencing Human Umbilical Vein Endothelial Cells - metabolism Humans immune response inflammation Integrins - immunology Integrins - metabolism Lymphocytes - cytology Lymphocytes - metabolism microtubules Microtubules - immunology Microtubules - metabolism mitochondria Mitochondria - immunology Mitochondria - metabolism Mitochondrial Proteins - metabolism myosin polymerization rho GTP-Binding Proteins - metabolism Signal Transduction - immunology
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