Essential Role of TID1 in Maintaining Mitochondrial Membrane Potential Homogeneity and Mitochondrial DNA Integrity

The tumorous imaginal disc 1 (TID1) protein localizes mainly to the mitochondrial compartment, wherein its function remains largely unknown. Here we report that TID1 regulates the steady-state homogeneity of the mitochondrial membrane potential (Δψ) and maintains the integrity of mitochondrial DNA (...

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Veröffentlicht in:	Molecular and cellular biology 2014-04, Vol.34 (8), p.1427-1437
Hauptverfasser:	Ng, Andy Cheuk-Him, Baird, Stephen D., Screaton, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Cells, Cultured DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Energy Metabolism - physiology HSP40 Heat-Shock Proteins - genetics HSP40 Heat-Shock Proteins - metabolism Humans Membrane Potential, Mitochondrial - genetics Membrane Potential, Mitochondrial - physiology Mitochondria - genetics Mitochondria - metabolism Signal Transduction - physiology
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