Angiotensin II Triggers Expression of the Adrenal Gland Zona Glomerulosa-Specific 3β-Hydroxysteroid Dehydrogenase Isoenzyme through De Novo Protein Synthesis of the Orphan Nuclear Receptors NGFIB and NURR1

The 3β-hydroxysteroid dehydrogenase (3β-HSD) is an enzyme crucial for steroid synthesis. Two different 3β-HSD isoforms exist in humans. Classically, HSD3B2 was considered the principal isoform present in the adrenal. However, we recently showed that the alternative isoform, HSD3B1, is expressed spec...

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Veröffentlicht in:	Molecular and cellular biology 2014-10, Vol.34 (20), p.3880-3894
Hauptverfasser:	Ota, Takumi, Doi, Masao, Yamazaki, Fumiyoshi, Yarimizu, Daisuke, Okada, Kazuki, Murai, Iori, Hayashi, Hida, Kunisue, Sumihiro, Nakagawa, Yuuki, Okamura, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - enzymology Angiotensin II - physiology Animals Binding Sites Cell Line Enzyme Induction Humans Isoenzymes - genetics Isoenzymes - metabolism Male Mice Mice, Inbred C57BL Multienzyme Complexes - genetics Multienzyme Complexes - metabolism Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism Nuclear Receptor Subfamily 4, Group A, Member 2 - genetics Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism Progesterone Reductase - genetics Progesterone Reductase - metabolism Protein Binding Protein Biosynthesis Response Elements Steroid Isomerases - genetics Steroid Isomerases - metabolism Transcription, Genetic
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