AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival

A major goal of cancer research is the identification of tumor-specific vulnerabilities that can be exploited for the development of therapies that are selectively toxic to the tumor. We show here that the transcriptional coactivators peroxisome proliferator-activated receptor gamma coactivator 1β (...

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Veröffentlicht in:	Molecular and cellular biology 2015-11, Vol.35 (22), p.3866-3879
Hauptverfasser:	Fisher, Kurt W., Das, Binita, Kim, Hyun Seok, Clymer, Beth K., Gehring, Drew, Smith, Deandra R., Costanzo-Garvey, Diane L., Fernandez, Mario R., Brattain, Michael G., Kelly, David L., MacMillan, John, White, Michael A., Lewis, Robert E.
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Animals Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line, Tumor Cell Survival Colon - metabolism Colon - pathology Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology ERRalpha Estrogen-Related Receptor Gene Expression Regulation, Neoplastic Humans Mice, Inbred BALB C Mice, Nude Protein Kinases - genetics Protein Kinases - metabolism Protein Subunits - metabolism Receptors, Estrogen - genetics Receptors, Estrogen - metabolism RNA-Binding Proteins Spotlight
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