Decreased Neuraminidase Activity Is Important for the Adaptation of H5N1 Influenza Virus to Human Airway Epithelium

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Veröffentlicht in:	Journal of Virology 2012-05, Vol.86 (9), p.4724-4733
Hauptverfasser:	ILYUSHINA, Natalia A, BOVIN, Nicolai V, WEBSTER, Robert G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Biological Amino Acid Substitution Animals Cell Line Dogs Drug Resistance, Viral - genetics Enzyme Activation - genetics Enzyme Inhibitors - pharmacology Genes, Viral Hemagglutinins - genetics Humans Influenza A Virus, H5N1 Subtype - drug effects Influenza A Virus, H5N1 Subtype - enzymology Influenza A Virus, H5N1 Subtype - genetics Influenza virus Kinetics Microbial Sensitivity Tests Mutation Neuraminidase - antagonists & inhibitors Neuraminidase - metabolism Receptors, Virus - metabolism Respiratory Mucosa - virology Ribonucleoproteins - metabolism Sequence Analysis, DNA Virus Replication - drug effects Virus Replication - genetics Virus-Cell Interactions
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