Attenuated West Nile Virus Mutant NS1 130-132QQA/175A/207A Exhibits Virus-Induced Ultrastructural Changes and Accumulation of Protein in the Endoplasmic Reticulum

We have previously shown that ablation of the three N-linked glycosylation sites in the West Nile virus NS1 protein completely attenuates mouse neuroinvasiveness (≥1,000,000 PFU). Here, we compared the replication of the NS1 130-132QQA/175A/207A mutant to that of the parental NY99 strain in monkey k...

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Veröffentlicht in:	Journal of virology 2015-01, Vol.89 (2), p.1474-1478
Hauptverfasser:	Whiteman, Melissa C., Popov, Vsevolod, Sherman, Michael B., Wen, Julie, Barrett, Alan D. T.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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