Cell Cycle Arrest in G 2 /M Phase Enhances Replication of Interferon-Sensitive Cytoplasmic RNA Viruses via Inhibition of Antiviral Gene Expression

Vesicular stomatitis virus (VSV) (a rhabdovirus) and its variant VSV-ΔM51 are widely used model systems to study mechanisms of virus-host interactions. Here, we investigated how the cell cycle affects replication of these viruses using an array of cell lines with different levels of impairment of an...

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Veröffentlicht in:	Journal of virology 2019-02, Vol.93 (4)
Hauptverfasser:	Bressy, Christian, Droby, Gaith N, Maldonado, Bryant D, Steuerwald, Nury, Grdzelishvili, Valery Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - pharmacology Cell Cycle Checkpoints - genetics Cell Cycle Checkpoints - physiology Cell Line, Tumor Cytoplasm G2 Phase - physiology G2 Phase Cell Cycle Checkpoints - physiology Gene Expression - genetics Humans Interferon Type I - metabolism Interferon-gamma - metabolism Interferons M Phase Cell Cycle Checkpoints - physiology Oncolytic Virotherapy - methods Oncolytic Viruses - genetics RNA Viruses - immunology RNA Viruses - metabolism Sendai virus - genetics Sendai virus - metabolism Signal Transduction Vesicular stomatitis Indiana virus - genetics Vesiculovirus - genetics Vesiculovirus - metabolism Viral Matrix Proteins - genetics Virus Replication - genetics Virus Replication - immunology
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