Defective Human Immunodeficiency Virus-Specific CD8+ T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral Therapy
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| Veröffentlicht in: | Journal of Virology 2009-11, Vol.83 (22), p.11876-11889 |
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| container_title | Journal of Virology |
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| creator | Migueles, Stephen A Weeks, Kristin A Nou, Eric Berkley, Amy M Rood, Julia E Osborne, Christine M Hallahan, Claire W Cogliano-Shutta, Nancy A Metcalf, Julia A McLaughlin, Mary Kwan, Richard Mican, JoAnn M Davey, Jr, Richard T Connors, Mark |
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| doi_str_mv | 10.1128/JVI.01153-09 |
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</description><identifier>ISSN: 0022-538X</identifier><identifier>EISSN: 1098-5514</identifier><identifier>DOI: 10.1128/JVI.01153-09</identifier><identifier>PMID: 19726501</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Adolescent ; Anti-HIV Agents - pharmacology ; Anti-HIV Agents - therapeutic use ; Biological and medical sciences ; CD4 Lymphocyte Count ; CD4-CD8 Ratio ; CD8-Positive T-Lymphocytes - drug effects ; CD8-Positive T-Lymphocytes - physiology ; CD8-Positive T-Lymphocytes - virology ; Cell Transformation, Viral - drug effects ; Cell Transformation, Viral - immunology ; Child ; Child, Preschool ; Disease Progression ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; HIV Infections - drug therapy ; HIV Infections - immunology ; Humans ; Lymphocyte Activation - immunology ; Microbiology ; Miscellaneous ; RNA, Viral - metabolism ; Vaccines and Antiviral Agents ; Virology ; Young Adult</subject><ispartof>Journal of Virology, 2009-11, Vol.83 (22), p.11876-11889</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright © 2009, American Society for Microbiology 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-74d9b446444c60ff0867e3d978d878f0ba1b45414b93316aa4039619f084bc8b3</citedby><cites>FETCH-LOGICAL-c484t-74d9b446444c60ff0867e3d978d878f0ba1b45414b93316aa4039619f084bc8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772718/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772718/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22086340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19726501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Migueles, Stephen A</creatorcontrib><creatorcontrib>Weeks, Kristin A</creatorcontrib><creatorcontrib>Nou, Eric</creatorcontrib><creatorcontrib>Berkley, Amy M</creatorcontrib><creatorcontrib>Rood, Julia E</creatorcontrib><creatorcontrib>Osborne, Christine M</creatorcontrib><creatorcontrib>Hallahan, Claire W</creatorcontrib><creatorcontrib>Cogliano-Shutta, Nancy A</creatorcontrib><creatorcontrib>Metcalf, Julia A</creatorcontrib><creatorcontrib>McLaughlin, Mary</creatorcontrib><creatorcontrib>Kwan, Richard</creatorcontrib><creatorcontrib>Mican, JoAnn M</creatorcontrib><creatorcontrib>Davey, Jr, Richard T</creatorcontrib><creatorcontrib>Connors, Mark</creatorcontrib><title>Defective Human Immunodeficiency Virus-Specific CD8+ T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral Therapy</title><title>Journal of Virology</title><addtitle>J Virol</addtitle><description>Article Usage Stats
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</description><subject>Adolescent</subject><subject>Anti-HIV Agents - pharmacology</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>CD4-CD8 Ratio</subject><subject>CD8-Positive T-Lymphocytes - drug effects</subject><subject>CD8-Positive T-Lymphocytes - physiology</subject><subject>CD8-Positive T-Lymphocytes - virology</subject><subject>Cell Transformation, Viral - drug effects</subject><subject>Cell Transformation, Viral - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Disease Progression</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>Humans</subject><subject>Lymphocyte Activation - immunology</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>RNA, Viral - metabolism</subject><subject>Vaccines and Antiviral Agents</subject><subject>Virology</subject><subject>Young Adult</subject><issn>0022-538X</issn><issn>1098-5514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkcFv0zAYxS0EYqVw44wsIU40w46dxLkgTdlgnSaYoEzcLMexV0-JXdlOR_6U_bdz12rAydLz773Pnx8AbzE6xjhnny6ul8cI44JkqH4GZhjVLCsKTJ-DGUJ5nhWE_T4Cr0K4RQhTWtKX4AjXVV4WCM_A_anSSkazVfB8HISFy2EYreuUNtIoKyd4bfwYsp8bJU3SYHPKPsJV1qi-h1eun_Rok91Z0Zs4LeCVd73RyoudtoDCdrCZoovuT8qLEzzxCn5zEf5QITqvOtgmzUbjVfRua7zo4Wqd7JvpNXihRR_Um8M5B7--nK2a8-zy-9dlc3KZScpozCra1e1uLUplibRGrKwU6eqKdaxiGrUCt7SgmLY1IbgUgiJSl7hOIG0la8kcfN7nbsZ2UJ1UNqZX8I03g_ATd8Lw_2-sWfMbt-V5VeUVZilgsQ-Q3oXglX7yYsR3FfFUEX-siKM64e_-nfcXPnSSgA8HQAQpeu2FlSY8cXmeViRpizl4v-fW5mZ9l36QizDw263hjCQqjWZVSR4A2V6oEw</recordid><startdate>20091115</startdate><enddate>20091115</enddate><creator>Migueles, Stephen A</creator><creator>Weeks, Kristin A</creator><creator>Nou, Eric</creator><creator>Berkley, Amy M</creator><creator>Rood, Julia E</creator><creator>Osborne, Christine M</creator><creator>Hallahan, Claire W</creator><creator>Cogliano-Shutta, Nancy A</creator><creator>Metcalf, Julia A</creator><creator>McLaughlin, Mary</creator><creator>Kwan, Richard</creator><creator>Mican, JoAnn M</creator><creator>Davey, Jr, Richard T</creator><creator>Connors, Mark</creator><general>American Society for Microbiology</general><general>American Society for Microbiology (ASM)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20091115</creationdate><title>Defective Human Immunodeficiency Virus-Specific CD8+ T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral Therapy</title><author>Migueles, Stephen A ; Weeks, Kristin A ; Nou, Eric ; Berkley, Amy M ; Rood, Julia E ; Osborne, Christine M ; Hallahan, Claire W ; Cogliano-Shutta, Nancy A ; Metcalf, Julia A ; McLaughlin, Mary ; Kwan, Richard ; Mican, JoAnn M ; Davey, Jr, Richard T ; Connors, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-74d9b446444c60ff0867e3d978d878f0ba1b45414b93316aa4039619f084bc8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Anti-HIV Agents - pharmacology</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>CD4 Lymphocyte Count</topic><topic>CD4-CD8 Ratio</topic><topic>CD8-Positive T-Lymphocytes - drug effects</topic><topic>CD8-Positive T-Lymphocytes - physiology</topic><topic>CD8-Positive T-Lymphocytes - virology</topic><topic>Cell Transformation, Viral - drug effects</topic><topic>Cell Transformation, Viral - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Disease Progression</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>19726501</pmid><doi>10.1128/JVI.01153-09</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-538X |
| ispartof | Journal of Virology, 2009-11, Vol.83 (22), p.11876-11889 |
| issn | 0022-538X 1098-5514 |
| language | eng |
| recordid | cdi_crossref_primary_10_1128_JVI_01153_09 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adolescent Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Biological and medical sciences CD4 Lymphocyte Count CD4-CD8 Ratio CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - physiology CD8-Positive T-Lymphocytes - virology Cell Transformation, Viral - drug effects Cell Transformation, Viral - immunology Child Child, Preschool Disease Progression Flow Cytometry Fundamental and applied biological sciences. Psychology HIV Infections - drug therapy HIV Infections - immunology Humans Lymphocyte Activation - immunology Microbiology Miscellaneous RNA, Viral - metabolism Vaccines and Antiviral Agents Virology Young Adult |
| title | Defective Human Immunodeficiency Virus-Specific CD8+ T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral Therapy |
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