A Unique T-Cell Receptor Amino Acid Sequence Selected by Human T-Cell Lymphotropic Virus Type 1 Tax 301-309 -Specific Cytotoxic T Cells in HLA-A24:02-Positive Asymptomatic Carriers and Adult T-Cell Leukemia/Lymphoma Patients

We previously reported that the T-cell receptor (TCR) repertoire of human T-cell lymphotropic virus type 1 (HTLV-1) Tax -specific CD8 cytotoxic T cells (Tax -CTLs) was highly restricted and a particular amino acid sequence motif, the PDR motif, was conserved among HLA-A*24:02-positive (HLA-A*24:02 )...

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Veröffentlicht in:	Journal of virology 2017-10, Vol.91 (19)
Hauptverfasser:	Ishihara, Yuko, Tanaka, Yukie, Kobayashi, Seiichiro, Kawamura, Koji, Nakasone, Hideki, Gomyo, Ayumi, Hayakawa, Jin, Tamaki, Masaharu, Akahoshi, Yu, Harada, Naonori, Kusuda, Machiko, Kameda, Kazuaki, Ugai, Tomotaka, Wada, Hidenori, Sakamoto, Kana, Sato, Miki, Terasako-Saito, Kiriko, Kikuchi, Misato, Kimura, Shun-Ichi, Tanihara, Aki, Kako, Shinichi, Uchimaru, Kaoru, Kanda, Yoshinobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence - genetics Antigens, CD7 - metabolism Cell Adhesion Molecule-1 Cell Adhesion Molecules - metabolism Cells, Cultured Gene Products, tax - genetics Gene Products, tax - immunology HLA-A24 Antigen - genetics HLA-A24 Antigen - immunology HTLV-I Infections - pathology HTLV-I Infections - virology Human T-lymphotropic virus 1 - genetics Human T-lymphotropic virus 1 - immunology Humans Immunoglobulins - metabolism Immunologic Memory - immunology Leukemia-Lymphoma, Adult T-Cell - genetics Leukemia-Lymphoma, Adult T-Cell - immunology Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology T-Lymphocytes, Cytotoxic - immunology
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