Induction of Neutrophil Chemotaxis by the Quorum-Sensing Molecule N-(3-Oxododecanoyl)-L-Homoserine Lactone

Acyl homoserine lactones are synthesized by Pseudomonas aeruginosa as signaling molecules which control production of virulence factors and biofilm formation in a paracrine manner. We found that N-(3-oxododecanoyl)-L-homoserine lactone (3OC12-HSL), but not its 3-deoxo isomer or acyl-homoserine lacto...

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Veröffentlicht in:	Infection and Immunity 2006-10, Vol.74 (10), p.5687-5692
Hauptverfasser:	Zimmermann, Sabine, Wagner, Christof, Müller, Wencke, Brenner-Weiss, Gerald, Hug, Friederike, Prior, Birgit, Obst, Ursula, Hänsch, Gertrud Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - metabolism 4-Butyrolactone - pharmacology Bacterial Infections Biofilms - growth & development Biological and medical sciences Chemotaxis, Leukocyte Fundamental and applied biological sciences. Psychology Homoserine - analogs & derivatives Homoserine - metabolism Homoserine - pharmacology Humans Microbiology Neutrophils - drug effects Neutrophils - immunology Pseudomonas aeruginosa Pseudomonas aeruginosa - metabolism Pseudomonas aeruginosa - physiology Signal Transduction
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