Phagocytosis of Borrelia burgdorferi and Treponema pallidum Potentiates Innate Immune Activation and Induces Gamma Interferon Production

We examined the interactions of live and lysed spirochetes with innate immune cells. THP-1 monocytoid cells were activated to comparable extents by live Borrelia burgdorferi and by B. burgdorferi and Treponema pallidum lysates but were poorly activated by live T. pallidum. Because THP-1 cells poorly...

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Veröffentlicht in:	Infection and Immunity 2007-04, Vol.75 (4), p.2046-2062
Hauptverfasser:	Moore, Meagan W, Cruz, Adriana R, LaVake, Carson J, Marzo, Amanda L, Eggers, Christian H, Salazar, Juan C, Radolf, Justin D
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriology Biological and medical sciences Borrelia burgdorferi Borrelia burgdorferi - immunology Cell Line Cells, Cultured Cytochalasin D - pharmacology Dendritic Cells - immunology Flow Cytometry Fundamental and applied biological sciences. Psychology Host Response and Inflammation Humans Immunity, Innate Immunologic Factors - pharmacology Interferon-gamma - biosynthesis Killer Cells, Natural - immunology Leukocyte Reduction Procedures Lymphocytes - immunology Microbiology Miscellaneous Monocytes - immunology Monocytes - microbiology Phagocytosis Serum - immunology Treponema pallidum Treponema pallidum - immunology
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