The Combinations Chitosan-Pam 3 CSK 4 and Chitosan-Monophosphoryl Lipid A: Promising Immune-Enhancing Adjuvants for Anticaries Vaccine PAc

We previously demonstrated that recombinant protein PAc could be administered as an anticaries vaccine. However, the relatively weak immunogenicity of PAc limits its application. In the present study, we investigated the effect of two adjuvant combinations of chitosan plus Pam CSK (chitosan-Pam CSK...

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Veröffentlicht in:	Infection and immunity 2019-12, Vol.87 (12)
Hauptverfasser:	Bi, Yongli, Xu, Qingan, Su, Lingkai, Xu, Jiantao, Liu, Zhongfang, Yang, Ying, Tang, Hua, Li, Yuhong, Fan, Mingwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Animals Bacterial Vaccines - immunology Chitosan - pharmacology Dental Caries - microbiology Dental Caries - prevention & control Female Immunogenicity, Vaccine - immunology Immunoglobulin A, Secretory - analysis Lipid A - analogs & derivatives Lipid A - immunology Lipopeptides - pharmacology Membrane Proteins - immunology Mice Mice, Inbred C57BL NLR Proteins - agonists Streptococcus mutans - immunology Streptococcus mutans - pathogenicity Toll-Like Receptors - agonists Vaccines, Synthetic - immunology Virulence Factors - immunology
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