Functional Characterization of LcpA, a Surface-Exposed Protein of Leptospira spp. That Binds the Human Complement Regulator C4BP

We have previously shown that pathogenic leptospiral strains are able to bind C4b binding protein (C4BP). Surface-bound C4BP retains its cofactor activity, indicating that acquisition of this complement regulator may contribute to leptospiral serum resistance. In the present study, the abilities of...

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Veröffentlicht in:	Infection and Immunity 2010-07, Vol.78 (7), p.3207-3216
Hauptverfasser:	Barbosa, Angela S, Monaris, Denize, Silva, Ludmila B, Morais, Zenaide M, Vasconcellos, Sílvio A, Cianciarullo, Aurora M, Isaac, Lourdes, Abreu, Patricia A.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Bacterial Outer Membrane Proteins - physiology Bacteriology Biological and medical sciences Blotting, Western Cloning, Molecular Complement C4b-Binding Protein Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Genes, Bacterial - genetics Genes, Bacterial - physiology Histocompatibility Antigens Host Response and Inflammation Humans Immunoblotting Leptospira Leptospira - genetics Leptospira - immunology Leptospira - physiology Leptospira interrogans - immunology Leptospirosis - microbiology Microbiology Microscopy, Immunoelectron Miscellaneous Open Reading Frames - genetics Polymerase Chain Reaction Recombinant Proteins
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