Long-Term Observation of Subunit Vaccine F1-rV270 against Y ersinia pestis in Mice

Long-Term Observation of Subunit Vaccine F1-rV270 against Y ersinia pestis in Mice

Long-term protection and antibody response for the subunit vaccine F1-rV270 were determined by using the mouse model. Antibodies to F1 and rV270 were still detectable over a period of 518 days. The complete protection against lethal challenge of Yersinia pestis could be achieved up to day 518 after...

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Veröffentlicht in:Clinical and vaccine immunology 2010-01, Vol.17 (1), p.199-201
Hauptverfasser: Wang, Zuyun, Zhou, Lei, Qi, Zhizhen, Zhang, Qingwen, Dai, Ruixia, Yang, Yonghai, Cui, Baizhong, Wang, Hu, Yang, Ruifu, Wang, Xiaoyi
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Sprache:eng
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Zusammenfassung:Long-term protection and antibody response for the subunit vaccine F1-rV270 were determined by using the mouse model. Antibodies to F1 and rV270 were still detectable over a period of 518 days. The complete protection against lethal challenge of Yersinia pestis could be achieved up to day 518 after primary immunization.
ISSN:1556-6811
1556-679X
DOI:10.1128/CVI.00305-09