High-Level Biosynthesis of the Anteiso-C 17 Isoform of the Antibiotic Mycosubtilin in Bacillus subtilis and Characterization of Its Candidacidal Activity

High-level production (880 mg liter −1 ) and isolation of the anteiso-C 17 isoform of the lipopeptide mycosubtilin produced by a genetically engineered Bacillus subtilis strain are reported. Antifungal activity of this isoform, as determined via culture and fluorometric and cell leakage assays, sugg...

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Veröffentlicht in:	Applied and environmental microbiology 2009-07, Vol.75 (13), p.4636-4640
Hauptverfasser:	Fickers, Patrick, Guez, Jean-Sébastien, Damblon, Christian, Leclère, Valérie, Béchet, Max, Jacques, Philippe, Joris, Bernard
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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