Understanding the Molecular Determinants of Substrate and Inhibitor Specificities in the Carbapenemase KPC-2: Exploring the Roles of Arg220 and Glu276
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| Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2012-08, Vol.56 (8), p.4428-4438 |
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| container_title | Antimicrobial Agents and Chemotherapy |
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| creator | PAPP-WALLACE, Krisztina M TARACILA, Magdalena A SMITH, Kerri M YAN XU BONOMOA, Robert A |
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| doi_str_mv | 10.1128/aac.05769-11 |
| format | Article |
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1752 N Street N.W. • Washington DC 20036
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Print ISSN:
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</description><subject>Amino Acid Sequence</subject><subject>Amino Acid Substitution</subject><subject>Antibiotics. Antiinfectious agents. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>22687511</pmid><doi>10.1128/aac.05769-11</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 2012-08, Vol.56 (8), p.4428-4438 |
| issn | 0066-4804 1098-6596 |
| language | eng |
| recordid | cdi_crossref_primary_10_1128_AAC_05769_11 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Amino Acid Sequence Amino Acid Substitution Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Proteins Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism beta-Lactam Resistance beta-Lactam Resistance - genetics beta-Lactamases beta-Lactamases - chemistry beta-Lactamases - genetics beta-Lactamases - metabolism beta-Lactams - chemistry beta-Lactams - metabolism Biological and medical sciences Catalytic Domain Clavulanic Acid - chemistry Clavulanic Acid - metabolism Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Mechanisms of Resistance Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Protein Structure, Quaternary Sequence Analysis, Protein Structure-Activity Relationship |
| title | Understanding the Molecular Determinants of Substrate and Inhibitor Specificities in the Carbapenemase KPC-2: Exploring the Roles of Arg220 and Glu276 |
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