Inhibitors of Leishmania GDP-Mannose Pyrophosphorylase Identified by High-Throughput Screening of Small-Molecule Chemical Library
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| Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2010-05, Vol.54 (5), p.1712-1719 |
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| creator | LACKOVIC, Kurt PARISOT, John P SLEEBS, Nerida BAELL, Jonathan B DEBIEN, Laurent WATSON, Keith G CURTIS, Joan M HANDMAN, Emanuela STREET, Ian P KEDZIERSKI, Lukasz |
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| doi_str_mv | 10.1128/AAC.01634-09 |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.01634-09</identifier><identifier>PMID: 20160053</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiprotozoal Agents ; Antiprotozoal Agents - chemistry ; Antiprotozoal Agents - pharmacology ; Biological and medical sciences ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Design ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - pharmacology ; Fibroblasts - cytology ; Fibroblasts - parasitology ; Humans ; Leishmania ; Leishmania major ; Leishmania major - drug effects ; Leishmania major - enzymology ; Leishmaniasis, Cutaneous ; Leishmaniasis, Cutaneous - drug therapy ; Leishmaniasis, Cutaneous - parasitology ; Medical sciences ; Nucleotidyltransferases ; Nucleotidyltransferases - antagonists & inhibitors ; Nucleotidyltransferases - metabolism ; Pharmacology. Drug treatments ; Pyrazoles - pharmacology ; Quinolines - pharmacology ; Small Molecule Libraries ; Susceptibility ; Thiadiazoles - pharmacology</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2010-05, Vol.54 (5), p.1712-1719</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 American Society for Microbiology</rights><rights>Copyright © 2010, American Society for Microbiology 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a505t-523bed1bcc49d4fa2c800317057689c3ad457ad7789f5fa2dcc9e96b4c8cc21f3</citedby><cites>FETCH-LOGICAL-a505t-523bed1bcc49d4fa2c800317057689c3ad457ad7789f5fa2dcc9e96b4c8cc21f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863604/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863604/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22730465$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20160053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LACKOVIC, Kurt</creatorcontrib><creatorcontrib>PARISOT, John P</creatorcontrib><creatorcontrib>SLEEBS, Nerida</creatorcontrib><creatorcontrib>BAELL, Jonathan B</creatorcontrib><creatorcontrib>DEBIEN, Laurent</creatorcontrib><creatorcontrib>WATSON, Keith G</creatorcontrib><creatorcontrib>CURTIS, Joan M</creatorcontrib><creatorcontrib>HANDMAN, Emanuela</creatorcontrib><creatorcontrib>STREET, Ian P</creatorcontrib><creatorcontrib>KEDZIERSKI, Lukasz</creatorcontrib><title>Inhibitors of Leishmania GDP-Mannose Pyrophosphorylase Identified by High-Throughput Screening of Small-Molecule Chemical Library</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>AAC</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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</description><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiprotozoal Agents</subject><subject>Antiprotozoal Agents - chemistry</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Design</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - parasitology</subject><subject>Humans</subject><subject>Leishmania</subject><subject>Leishmania major</subject><subject>Leishmania major - drug effects</subject><subject>Leishmania major - enzymology</subject><subject>Leishmaniasis, Cutaneous</subject><subject>Leishmaniasis, Cutaneous - drug therapy</subject><subject>Leishmaniasis, Cutaneous - parasitology</subject><subject>Medical sciences</subject><subject>Nucleotidyltransferases</subject><subject>Nucleotidyltransferases - antagonists & inhibitors</subject><subject>Nucleotidyltransferases - metabolism</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antiprotozoal Agents</topic><topic>Antiprotozoal Agents - chemistry</topic><topic>Antiprotozoal Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Design</topic><topic>Enzyme Inhibitors - chemistry</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - parasitology</topic><topic>Humans</topic><topic>Leishmania</topic><topic>Leishmania major</topic><topic>Leishmania major - drug effects</topic><topic>Leishmania major - enzymology</topic><topic>Leishmaniasis, Cutaneous</topic><topic>Leishmaniasis, Cutaneous - drug therapy</topic><topic>Leishmaniasis, Cutaneous - parasitology</topic><topic>Medical sciences</topic><topic>Nucleotidyltransferases</topic><topic>Nucleotidyltransferases - antagonists & inhibitors</topic><topic>Nucleotidyltransferases - metabolism</topic><topic>Pharmacology. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>20160053</pmid><doi>10.1128/AAC.01634-09</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 2010-05, Vol.54 (5), p.1712-1719 |
| issn | 0066-4804 1098-6596 |
| language | eng |
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| source | MEDLINE; PubMed Central; EZB Electronic Journals Library |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antiprotozoal Agents Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Biological and medical sciences Cells, Cultured Dose-Response Relationship, Drug Drug Design Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Fibroblasts - cytology Fibroblasts - parasitology Humans Leishmania Leishmania major Leishmania major - drug effects Leishmania major - enzymology Leishmaniasis, Cutaneous Leishmaniasis, Cutaneous - drug therapy Leishmaniasis, Cutaneous - parasitology Medical sciences Nucleotidyltransferases Nucleotidyltransferases - antagonists & inhibitors Nucleotidyltransferases - metabolism Pharmacology. Drug treatments Pyrazoles - pharmacology Quinolines - pharmacology Small Molecule Libraries Susceptibility Thiadiazoles - pharmacology |
| title | Inhibitors of Leishmania GDP-Mannose Pyrophosphorylase Identified by High-Throughput Screening of Small-Molecule Chemical Library |
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