A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro
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| Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2007-06, Vol.51 (6), p.2143-2155 |
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| creator | AMANO, Masayuki KOH, Yasuhiro DAS, Debananda JIANFENG LI LESCHENKO, Sofiya WANG, Yuan-Fang BOROSS, Peter I WEBER, Irene T GHOSH, Arun K MITSUYA, Hiroaki |
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| doi_str_mv | 10.1128/aac.01413-06 |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/aac.01413-06</identifier><identifier>PMID: 17371811</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Amino Acid Sequence ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral Agents ; Biological and medical sciences ; Drug Design ; Drug Resistance, Multiple, Viral ; Furans ; Furans - chemical synthesis ; Furans - chemistry ; Furans - pharmacology ; HIV Infections - virology ; HIV Protease - chemistry ; HIV Protease - genetics ; HIV Protease Inhibitors ; HIV Protease Inhibitors - chemical synthesis ; HIV Protease Inhibitors - chemistry ; HIV Protease Inhibitors - pharmacology ; HIV-1 ; HIV-1 - drug effects ; HIV-1 - enzymology ; HIV-1 - pathogenicity ; HIV-1 - physiology ; Human immunodeficiency virus 1 ; Human immunodeficiency virus 2 ; Humans ; Inhibitory Concentration 50 ; Medical sciences ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Sequence Data ; Pharmacology. Drug treatments ; Sulfonamides ; Sulfonamides - chemical synthesis ; Sulfonamides - chemistry ; Sulfonamides - pharmacology ; Urethane ; Urethane - chemical synthesis ; Urethane - chemistry ; Urethane - pharmacology ; Virus Replication - drug effects</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2007-06, Vol.51 (6), p.2143-2155</ispartof><rights>2007 INIST-CNRS</rights><rights>Copyright © 2007 American Society for Microbiology</rights><rights>Copyright © 2007, American Society for Microbiology 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a569t-a6936bd8d250ee49c786a788845a54a457be7d31e8039bc9810d0c6d04bb19a3</citedby><cites>FETCH-LOGICAL-a569t-a6936bd8d250ee49c786a788845a54a457be7d31e8039bc9810d0c6d04bb19a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891396/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891396/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18798094$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17371811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AMANO, Masayuki</creatorcontrib><creatorcontrib>KOH, Yasuhiro</creatorcontrib><creatorcontrib>DAS, Debananda</creatorcontrib><creatorcontrib>JIANFENG LI</creatorcontrib><creatorcontrib>LESCHENKO, Sofiya</creatorcontrib><creatorcontrib>WANG, Yuan-Fang</creatorcontrib><creatorcontrib>BOROSS, Peter I</creatorcontrib><creatorcontrib>WEBER, Irene T</creatorcontrib><creatorcontrib>GHOSH, Arun K</creatorcontrib><creatorcontrib>MITSUYA, Hiroaki</creatorcontrib><title>A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>AAC</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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</description><subject>Amino Acid Sequence</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral Agents</subject><subject>Biological and medical sciences</subject><subject>Drug Design</subject><subject>Drug Resistance, Multiple, Viral</subject><subject>Furans</subject><subject>Furans - chemical synthesis</subject><subject>Furans - chemistry</subject><subject>Furans - pharmacology</subject><subject>HIV Infections - virology</subject><subject>HIV Protease - chemistry</subject><subject>HIV Protease - genetics</subject><subject>HIV Protease Inhibitors</subject><subject>HIV Protease Inhibitors - chemical synthesis</subject><subject>HIV Protease Inhibitors - chemistry</subject><subject>HIV Protease Inhibitors - pharmacology</subject><subject>HIV-1</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - enzymology</subject><subject>HIV-1 - pathogenicity</subject><subject>HIV-1 - physiology</subject><subject>Human immunodeficiency virus 1</subject><subject>Human immunodeficiency virus 2</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Models, Molecular</subject><subject>Molecular Sequence Data</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral Agents</topic><topic>Biological and medical sciences</topic><topic>Drug Design</topic><topic>Drug Resistance, Multiple, Viral</topic><topic>Furans</topic><topic>Furans - chemical synthesis</topic><topic>Furans - chemistry</topic><topic>Furans - pharmacology</topic><topic>HIV Infections - virology</topic><topic>HIV Protease - chemistry</topic><topic>HIV Protease - genetics</topic><topic>HIV Protease Inhibitors</topic><topic>HIV Protease Inhibitors - chemical synthesis</topic><topic>HIV Protease Inhibitors - chemistry</topic><topic>HIV Protease Inhibitors - pharmacology</topic><topic>HIV-1</topic><topic>HIV-1 - drug effects</topic><topic>HIV-1 - enzymology</topic><topic>HIV-1 - pathogenicity</topic><topic>HIV-1 - physiology</topic><topic>Human immunodeficiency virus 1</topic><topic>Human immunodeficiency virus 2</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Models, Molecular</topic><topic>Molecular Sequence Data</topic><topic>Pharmacology. Drug treatments</topic><topic>Sulfonamides</topic><topic>Sulfonamides - chemical synthesis</topic><topic>Sulfonamides - chemistry</topic><topic>Sulfonamides - pharmacology</topic><topic>Urethane</topic><topic>Urethane - chemical synthesis</topic><topic>Urethane - chemistry</topic><topic>Urethane - pharmacology</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AMANO, Masayuki</creatorcontrib><creatorcontrib>KOH, Yasuhiro</creatorcontrib><creatorcontrib>DAS, Debananda</creatorcontrib><creatorcontrib>JIANFENG LI</creatorcontrib><creatorcontrib>LESCHENKO, Sofiya</creatorcontrib><creatorcontrib>WANG, Yuan-Fang</creatorcontrib><creatorcontrib>BOROSS, Peter I</creatorcontrib><creatorcontrib>WEBER, Irene T</creatorcontrib><creatorcontrib>GHOSH, Arun K</creatorcontrib><creatorcontrib>MITSUYA, Hiroaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial Agents and Chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AMANO, Masayuki</au><au>KOH, Yasuhiro</au><au>DAS, Debananda</au><au>JIANFENG LI</au><au>LESCHENKO, Sofiya</au><au>WANG, Yuan-Fang</au><au>BOROSS, Peter I</au><au>WEBER, Irene T</au><au>GHOSH, Arun K</au><au>MITSUYA, Hiroaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro</atitle><jtitle>Antimicrobial Agents and Chemotherapy</jtitle><stitle>AAC</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>51</volume><issue>6</issue><spage>2143</spage><epage>2155</epage><pages>2143-2155</pages><issn>0066-4804</issn><eissn>1098-6596</eissn><coden>AACHAX</coden><abstract>Classifications
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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>17371811</pmid><doi>10.1128/aac.01413-06</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Antimicrobial Agents and Chemotherapy, 2007-06, Vol.51 (6), p.2143-2155 |
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| language | eng |
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| source | MEDLINE; PubMed Central(OpenAccess); Free E-Journal (出版社公開部分のみ） |
| subjects | Amino Acid Sequence Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Biological and medical sciences Drug Design Drug Resistance, Multiple, Viral Furans Furans - chemical synthesis Furans - chemistry Furans - pharmacology HIV Infections - virology HIV Protease - chemistry HIV Protease - genetics HIV Protease Inhibitors HIV Protease Inhibitors - chemical synthesis HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - pharmacology HIV-1 HIV-1 - drug effects HIV-1 - enzymology HIV-1 - pathogenicity HIV-1 - physiology Human immunodeficiency virus 1 Human immunodeficiency virus 2 Humans Inhibitory Concentration 50 Medical sciences Microbial Sensitivity Tests Models, Molecular Molecular Sequence Data Pharmacology. Drug treatments Sulfonamides Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology Urethane Urethane - chemical synthesis Urethane - chemistry Urethane - pharmacology Virus Replication - drug effects |
| title | A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro |
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