Newly Identified Antibacterial Compounds Are Topoisomerase Poisons in African Trypanosomes
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| Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2010-02, Vol.54 (2), p.620-626 |
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| container_title | Antimicrobial Agents and Chemotherapy |
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| creator | TANG, Sonya C SHAPIRO, Theresa A |
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| doi_str_mv | 10.1128/AAC.01025-09 |
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</description><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>DNA Topoisomerases, Type I - metabolism</subject><subject>DNA Topoisomerases, Type II - metabolism</subject><subject>DNA, Kinetoplast - drug effects</subject><subject>DNA, Kinetoplast - metabolism</subject><subject>Humans</subject><subject>Mechanisms of Action: Physiological Effects</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Parasitic Sensitivity Tests</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Protein Binding</topic><topic>Protozoan Proteins - antagonists & inhibitors</topic><topic>Protozoan Proteins - metabolism</topic><topic>Topoisomerase I Inhibitors</topic><topic>Topoisomerase II Inhibitors</topic><topic>Trypanocidal Agents</topic><topic>Trypanocidal Agents - chemistry</topic><topic>Trypanocidal Agents - metabolism</topic><topic>Trypanocidal Agents - pharmacology</topic><topic>Trypanocidal Agents - therapeutic use</topic><topic>Trypanosoma brucei</topic><topic>Trypanosoma brucei brucei - drug effects</topic><topic>Trypanosoma brucei brucei - enzymology</topic><topic>Trypanosoma brucei brucei - physiology</topic><topic>Trypanosomiasis, African</topic><topic>Trypanosomiasis, African - drug therapy</topic><topic>Trypanosomiasis, African - parasitology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TANG, Sonya C</creatorcontrib><creatorcontrib>SHAPIRO, Theresa A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial Agents and Chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TANG, Sonya C</au><au>SHAPIRO, Theresa A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Newly Identified Antibacterial Compounds Are Topoisomerase Poisons in African Trypanosomes</atitle><jtitle>Antimicrobial Agents and Chemotherapy</jtitle><stitle>AAC</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>54</volume><issue>2</issue><spage>620</spage><epage>626</epage><pages>620-626</pages><issn>0066-4804</issn><eissn>1098-6596</eissn><coden>AACHAX</coden><abstract>Classifications
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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>20008775</pmid><doi>10.1128/AAC.01025-09</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 2010-02, Vol.54 (2), p.620-626 |
| issn | 0066-4804 1098-6596 |
| language | eng |
| recordid | cdi_crossref_primary_10_1128_AAC_01025_09 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Blotting, Western DNA Topoisomerases, Type I - metabolism DNA Topoisomerases, Type II - metabolism DNA, Kinetoplast - drug effects DNA, Kinetoplast - metabolism Humans Mechanisms of Action: Physiological Effects Medical sciences Molecular Structure Parasitic Sensitivity Tests Pharmacology. Drug treatments Protein Binding Protozoan Proteins - antagonists & inhibitors Protozoan Proteins - metabolism Topoisomerase I Inhibitors Topoisomerase II Inhibitors Trypanocidal Agents Trypanocidal Agents - chemistry Trypanocidal Agents - metabolism Trypanocidal Agents - pharmacology Trypanocidal Agents - therapeutic use Trypanosoma brucei Trypanosoma brucei brucei - drug effects Trypanosoma brucei brucei - enzymology Trypanosoma brucei brucei - physiology Trypanosomiasis, African Trypanosomiasis, African - drug therapy Trypanosomiasis, African - parasitology |
| title | Newly Identified Antibacterial Compounds Are Topoisomerase Poisons in African Trypanosomes |
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