Receptor Tyrosine Kinase Inhibitors That Block Replication of Influenza A and Other Viruses

We have previously reported that two receptor tyrosine kinase inhibitors (RTKIs), called AG879 and tyrphostin A9 (A9), can each block the replication of influenza A virus in cultured cells. In this study, we further characterized the in vitro antiviral efficacies and specificities of these agents. T...

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2011-12, Vol.55 (12), p.5553-5559
Hauptverfasser:	Kumar, Naveen, Sharma, Nishi R, Ly, Hinh, Parslow, Tristram G, Liang, Yuying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antagonists & inhibitors Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral Agents - therapeutic use antiviral properties Biological and medical sciences Cali mammarenavirus Cell Line chemistry Chick Embryo Coronaviridae Cricetinae cultured cells cytotoxicity Disease Models, Animal DNA Viruses DNA Viruses - drug effects DNA Viruses - physiology drug effects drug resistance drug therapy Enzyme Inhibitors Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use herpes simplex Herpesviridae Human viral diseases Humans Infectious diseases Influenza A virus Influenza A Virus, H1N1 Subtype Influenza A Virus, H1N1 Subtype - drug effects Influenza A Virus, H1N1 Subtype - physiology Influenza A Virus, H3N2 Subtype Influenza A Virus, H3N2 Subtype - drug effects Influenza A Virus, H3N2 Subtype - physiology Influenza, Human Influenza, Human - drug therapy Influenza, Human - virology Medical sciences Mice mortality Murine respirovirus Orthomyxoviridae Infections Orthomyxoviridae Infections - drug therapy Orthomyxoviridae Infections - mortality Orthomyxoviridae Infections - virology pathogens pharmacology Pharmacology. Drug treatments physiology Pichinde virus Rats receptor protein-tyrosine kinase Receptor Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases - antagonists & inhibitors RNA RNA Viruses RNA Viruses - drug effects RNA Viruses - physiology Rotavirus Sendai virus therapeutic use therapeutics Treatment Outcome tyrosine Tyrphostins Tyrphostins - chemistry Tyrphostins - pharmacology Tyrphostins - therapeutic use Vero Cells Viral diseases Viral diseases of the respiratory system and ent viral diseases virology Virus Replication Virus Replication - drug effects viruses
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