Structure of the human voltage-gated sodium channel Na v 1.4 in complex with β1

Voltage-gated sodium (Na ) channels, which are responsible for action potential generation, are implicated in many human diseases. Despite decades of rigorous characterization, the lack of a structure of any human Na channel has hampered mechanistic understanding. Here, we report the cryo-electron m...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-10, Vol.362 (6412)
Hauptverfasser:	Pan, Xiaojing, Li, Zhangqiang, Zhou, Qiang, Shen, Huaizong, Wu, Kun, Huang, Xiaoshuang, Chen, Jiaofeng, Zhang, Juanrong, Zhu, Xuechen, Lei, Jianlin, Xiong, Wei, Gong, Haipeng, Xiao, Bailong, Yan, Nieng
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Amino Acid Sequence Channelopathies - genetics Channelopathies - metabolism Cryoelectron Microscopy Drug Discovery HEK293 Cells Humans Mutation NAV1.4 Voltage-Gated Sodium Channel - chemistry NAV1.4 Voltage-Gated Sodium Channel - genetics NAV1.4 Voltage-Gated Sodium Channel - ultrastructure Protein Domains Voltage-Gated Sodium Channel beta-4 Subunit - chemistry Voltage-Gated Sodium Channel beta-4 Subunit - genetics Voltage-Gated Sodium Channel beta-4 Subunit - ultrastructure
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