Aluminum Absorption and Distribution: Effect of Parathyroid Hormone
In rats, gastrointestinal aluminum absorption and tissue distribution were altered by parathyroid hormone; the resultant tissue concentrations were similar to those observed in dialysis patients with a fatal encephalopathy. In dialysis patients, serum aluminum and endogenous parathyroid hormone conc...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1977-09, Vol.197 (4309), p.1187-1189 |
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| container_end_page | 1189 |
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| container_issue | 4309 |
| container_start_page | 1187 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 197 |
| creator | Mayor, Gilbert H. Keiser, Joan A. Makdani, Dhirajlal Ku, Pao K. |
| description | In rats, gastrointestinal aluminum absorption and tissue distribution were altered by parathyroid hormone; the resultant tissue concentrations were similar to those observed in dialysis patients with a fatal encephalopathy. In dialysis patients, serum aluminum and endogenous parathyroid hormone concentrations are significantly correlated. These data suggest that aluminum toxicity in dialysis patients results from oral aluminum ingestion in the presence of hyperparathyroidism. |
| doi_str_mv | 10.1126/science.897661 |
| format | Article |
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In dialysis patients, serum aluminum and endogenous parathyroid hormone concentrations are significantly correlated. 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In dialysis patients, serum aluminum and endogenous parathyroid hormone concentrations are significantly correlated. These data suggest that aluminum toxicity in dialysis patients results from oral aluminum ingestion in the presence of hyperparathyroidism.</description><subject>Aluminum</subject><subject>Aluminum - blood</subject><subject>Aluminum - metabolism</subject><subject>Animals</subject><subject>Azides</subject><subject>Blood</subject><subject>Bone and Bones - metabolism</subject><subject>Brain - metabolism</subject><subject>Dialysis</subject><subject>Estrogen receptors</subject><subject>Estrogens</subject><subject>Hormones</subject><subject>Humans</subject><subject>Lectins</subject><subject>Male</subject><subject>Muscles - metabolism</subject><subject>Parathyroid Hormone - blood</subject><subject>Parathyroid Hormone - pharmacology</subject><subject>Plants</subject><subject>Rats</subject><subject>Renal Dialysis</subject><subject>Soybeans</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUMlOwzAUtBBbKVw5cfAPJDzXW8ytKoUiVYIDnKPEi3DVxJGdHPr3pEoFEqcnvVk0MwjdE8gJWYjHpL1ttc0LJYUgZ2hGQPFMLYCeoxkAFVkBkl-jm5R2ACOm6BW6nNgztFruh8a3Q4OXdQqx631ocdUa_OxTH309HB9PeO2c1T0ODn9Useq_DzF4gzchNqG1t-jCVftk7053jr5e1p-rTbZ9f31bLbeZpoz0Y4zaciIoUcWYAgThQKUtONNEVaKgShkpLVNGaMr1AiRzYJ2rqWHESMPoHOWTr44hpWhd2UXfVPFQEiiPW5SnLcqp3Sh4mATdUDfW_NL_w7vUh_hnJhnjXNAfkqBkOQ</recordid><startdate>19770916</startdate><enddate>19770916</enddate><creator>Mayor, Gilbert H.</creator><creator>Keiser, Joan A.</creator><creator>Makdani, Dhirajlal</creator><creator>Ku, Pao K.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19770916</creationdate><title>Aluminum Absorption and Distribution: Effect of Parathyroid Hormone</title><author>Mayor, Gilbert H. ; Keiser, Joan A. ; Makdani, Dhirajlal ; Ku, Pao K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-80be51631980950615037e854c19a68399d77e49d6c35c2074f0effb3d41d7d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Aluminum</topic><topic>Aluminum - blood</topic><topic>Aluminum - metabolism</topic><topic>Animals</topic><topic>Azides</topic><topic>Blood</topic><topic>Bone and Bones - metabolism</topic><topic>Brain - metabolism</topic><topic>Dialysis</topic><topic>Estrogen receptors</topic><topic>Estrogens</topic><topic>Hormones</topic><topic>Humans</topic><topic>Lectins</topic><topic>Male</topic><topic>Muscles - metabolism</topic><topic>Parathyroid Hormone - blood</topic><topic>Parathyroid Hormone - pharmacology</topic><topic>Plants</topic><topic>Rats</topic><topic>Renal Dialysis</topic><topic>Soybeans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mayor, Gilbert H.</creatorcontrib><creatorcontrib>Keiser, Joan A.</creatorcontrib><creatorcontrib>Makdani, Dhirajlal</creatorcontrib><creatorcontrib>Ku, Pao K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mayor, Gilbert H.</au><au>Keiser, Joan A.</au><au>Makdani, Dhirajlal</au><au>Ku, Pao K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aluminum Absorption and Distribution: Effect of Parathyroid Hormone</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1977-09-16</date><risdate>1977</risdate><volume>197</volume><issue>4309</issue><spage>1187</spage><epage>1189</epage><pages>1187-1189</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>In rats, gastrointestinal aluminum absorption and tissue distribution were altered by parathyroid hormone; the resultant tissue concentrations were similar to those observed in dialysis patients with a fatal encephalopathy. In dialysis patients, serum aluminum and endogenous parathyroid hormone concentrations are significantly correlated. These data suggest that aluminum toxicity in dialysis patients results from oral aluminum ingestion in the presence of hyperparathyroidism.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>897661</pmid><doi>10.1126/science.897661</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1977-09, Vol.197 (4309), p.1187-1189 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_crossref_primary_10_1126_science_897661 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Aluminum Aluminum - blood Aluminum - metabolism Animals Azides Blood Bone and Bones - metabolism Brain - metabolism Dialysis Estrogen receptors Estrogens Hormones Humans Lectins Male Muscles - metabolism Parathyroid Hormone - blood Parathyroid Hormone - pharmacology Plants Rats Renal Dialysis Soybeans |
| title | Aluminum Absorption and Distribution: Effect of Parathyroid Hormone |
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