Predisposition to Neoplastic Transformation Caused by Gene Replacement of H- ras 1

Homologous recombination was used to introduce a nominally transforming mutation into an endogenous H- ras 1 gene in Rat1 fibroblasts. Although both the mutant and the remaining normal allele were expressed equally, the heterozygous cells were not neoplastically transformed. Instead, spontaneously t...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1993-06, Vol.260 (5113), p.1524-1527
Hauptverfasser:	Finney, Robert E., Bishop, J. Michael
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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