Toxicology and Pharmacological Action of Anabaena flos-aquae Toxin
Calves, rats, ducks, and goldfish given lethal oral doses of bacteria-free lyophilized cell suspensions of toxic Anabaena flos-aquae died as a result of respiratory arrest. Experiments with selected animals and pharmacological preparations showed that the main effect of the toxin was production of a...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1975-02, Vol.187 (4176), p.542-544 |
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| container_issue | 4176 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Carmichael, Wayne W. Biggs, David F. Gorham, Paul R. |
| description | Calves, rats, ducks, and goldfish given lethal oral doses of bacteria-free lyophilized cell suspensions of toxic Anabaena flos-aquae died as a result of respiratory arrest. Experiments with selected animals and pharmacological preparations showed that the main effect of the toxin was production of a sustained postsynaptic depolarizing neuromuscular blockade. |
| doi_str_mv | 10.1126/science.803708 |
| format | Article |
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Experiments with selected animals and pharmacological preparations showed that the main effect of the toxin was production of a sustained postsynaptic depolarizing neuromuscular blockade.</description><subject>Administration, Oral</subject><subject>Algae</subject><subject>Animals</subject><subject>Blood</subject><subject>Cattle</subject><subject>Choroid plexus</subject><subject>Cyanobacteria</subject><subject>Diabetes mellitus</subject><subject>Dosage</subject><subject>Ducks</subject><subject>Goldfish</subject><subject>Hyperglycemia</subject><subject>Injections, Intravenous</subject><subject>Insulin</subject><subject>Neuromuscular Depolarizing Agents</subject><subject>Rats</subject><subject>Respiratory Insufficiency - chemically induced</subject><subject>Toxins</subject><subject>Toxins, Biological - pharmacology</subject><subject>Toxins, Biological - toxicity</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtPwzAQhC3EqxSunDj4D7is4zixj6XiJVWCQzlHm40NqdK4xK1E_z0pqUDitNLOfLPaYexawkTKJLuNVLuW3MSAysEcsZEEq4VNQB2zEYDKhIFcn7OLGJcAvWbVGTsd3CN2twhfNYUmvO84thV__cBuhT-LmrDhU9rUoeXB82mLJboWuW9CFPi5Rcf3cHvJTjw20V0d5pi9PdwvZk9i_vL4PJvOBakUNkLnlhwQGUwBjc4kVamHPNWlN8paiYlyFqpEE2pjpfYyzyiTgNpqrUyixmwy5FIXYuycL9ZdvcJuV0go9lUUhyqK4bkeuBmA9bZcuerX_l9exk3o_sJy1V-X6hv07mN2</recordid><startdate>19750214</startdate><enddate>19750214</enddate><creator>Carmichael, Wayne W.</creator><creator>Biggs, David F.</creator><creator>Gorham, Paul R.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19750214</creationdate><title>Toxicology and Pharmacological Action of Anabaena flos-aquae Toxin</title><author>Carmichael, Wayne W. ; Biggs, David F. ; Gorham, Paul R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-579ce0cc8a40a8561cd4f0745bf83991a23e90d25ca58915f176c610a59553823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Administration, Oral</topic><topic>Algae</topic><topic>Animals</topic><topic>Blood</topic><topic>Cattle</topic><topic>Choroid plexus</topic><topic>Cyanobacteria</topic><topic>Diabetes mellitus</topic><topic>Dosage</topic><topic>Ducks</topic><topic>Goldfish</topic><topic>Hyperglycemia</topic><topic>Injections, Intravenous</topic><topic>Insulin</topic><topic>Neuromuscular Depolarizing Agents</topic><topic>Rats</topic><topic>Respiratory Insufficiency - chemically induced</topic><topic>Toxins</topic><topic>Toxins, Biological - pharmacology</topic><topic>Toxins, Biological - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carmichael, Wayne W.</creatorcontrib><creatorcontrib>Biggs, David F.</creatorcontrib><creatorcontrib>Gorham, Paul R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carmichael, Wayne W.</au><au>Biggs, David F.</au><au>Gorham, Paul R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxicology and Pharmacological Action of Anabaena flos-aquae Toxin</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1975-02-14</date><risdate>1975</risdate><volume>187</volume><issue>4176</issue><spage>542</spage><epage>544</epage><pages>542-544</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Calves, rats, ducks, and goldfish given lethal oral doses of bacteria-free lyophilized cell suspensions of toxic Anabaena flos-aquae died as a result of respiratory arrest. Experiments with selected animals and pharmacological preparations showed that the main effect of the toxin was production of a sustained postsynaptic depolarizing neuromuscular blockade.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>803708</pmid><doi>10.1126/science.803708</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1975-02, Vol.187 (4176), p.542-544 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_crossref_primary_10_1126_science_803708 |
| source | MEDLINE; Science Magazine; Jstor Complete Legacy |
| subjects | Administration, Oral Algae Animals Blood Cattle Choroid plexus Cyanobacteria Diabetes mellitus Dosage Ducks Goldfish Hyperglycemia Injections, Intravenous Insulin Neuromuscular Depolarizing Agents Rats Respiratory Insufficiency - chemically induced Toxins Toxins, Biological - pharmacology Toxins, Biological - toxicity |
| title | Toxicology and Pharmacological Action of Anabaena flos-aquae Toxin |
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