Cholestyramine: Use as a New Therapeutic Approach for Chlordecone (Kepone) Poisoning

In rats, as reported in humans, chlordecone (Kepone) is excreted predominantly in the feces. Cholestyramine, an anion exchange resin, binds chlordecone in rat intestine, increases its excretion into the feces, and decreases its content in the tissues. The resin appears to offer a practical method fo...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1978-02, Vol.199 (4331), p.893-895
Hauptverfasser:	Boylan, James J., Egle, John L., Guzelian, Philip S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Bile - metabolism Chlordecone - metabolism Chlordecone - poisoning Cholestyramine Resin - therapeutic use Excretion Feces Feces - metabolism Inactivation, Metabolic Insecticides - poisoning Intestines Liver Male Pesticides Placebos Radioactive decay Rats Resins Tissue Distribution Tissue samples
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Beschreibung
Zusammenfassung:	In rats, as reported in humans, chlordecone (Kepone) is excreted predominantly in the feces. Cholestyramine, an anion exchange resin, binds chlordecone in rat intestine, increases its excretion into the feces, and decreases its content in the tissues. The resin appears to offer a practical method for treating chronic poisoning with this and possibly with other lipophilic toxins.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.74852