Astatine-211--Tellurium Radiocolloid Cures Experimental Malignant Ascites
An investigation of the efficacy of astatine-211—tellurium colloid for the treatment of experimental malignant ascites in mice reveals that this α-emitting radiocolloid can be curative without causing undue toxicity to normal tissue. By comparison, negatron-emitting phosphorus-32 as colloidal chromi...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1981-04, Vol.212 (4492), p.340-341 |
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| container_issue | 4492 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Bloomer, William D. McLaughlin, William H. Neirinckx, Rudi D. Adelstein, S. James Gordon, Phillip R. Ruth, Thomas J. Wolf, Alfred P. |
| description | An investigation of the efficacy of astatine-211—tellurium colloid for the treatment of experimental malignant ascites in mice reveals that this α-emitting radiocolloid can be curative without causing undue toxicity to normal tissue. By comparison, negatron-emitting phosphorus-32 as colloidal chromic phosphate had no antineoplastic activity. The most compelling explanation for this striking difference is the dense ionization and short range of action associated with α-emission. These results have important implications for the development and use of α -emitters as radiocolloid therapy for the treatment of human tumors. |
| doi_str_mv | 10.1126/science.7209534 |
| format | Article |
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James ; Gordon, Phillip R. ; Ruth, Thomas J. ; Wolf, Alfred P.</creator><creatorcontrib>Bloomer, William D. ; McLaughlin, William H. ; Neirinckx, Rudi D. ; Adelstein, S. James ; Gordon, Phillip R. ; Ruth, Thomas J. ; Wolf, Alfred P.</creatorcontrib><description>An investigation of the efficacy of astatine-211—tellurium colloid for the treatment of experimental malignant ascites in mice reveals that this α-emitting radiocolloid can be curative without causing undue toxicity to normal tissue. By comparison, negatron-emitting phosphorus-32 as colloidal chromic phosphate had no antineoplastic activity. The most compelling explanation for this striking difference is the dense ionization and short range of action associated with α-emission. These results have important implications for the development and use of α -emitters as radiocolloid therapy for the treatment of human tumors.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.7209534</identifier><identifier>PMID: 7209534</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>550603 - Medicine- External Radiation in Therapy- (1980-) ; 560162 - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells ; ALPHA DECAY RADIOISOTOPES ; Alpha Particles ; ANIMALS ; Antineoplastics ; Ascites ; Ascites - radiotherapy ; Astatine ; Astatine - therapeutic use ; ASTATINE 211 ; ASTATINE ISOTOPES ; BETA DECAY RADIOISOTOPES ; CELL KILLING ; Cell Survival - radiation effects ; Chromium - therapeutic use ; Chromium Compounds ; COLLOIDS ; DATA ; DISPERSIONS ; DOSE-RESPONSE RELATIONSHIPS ; EHRLICH ASCITES TUMOR ; ELECTRON CAPTURE RADIOISOTOPES ; ELEMENTS ; ENERGY TRANSFER ; EXPERIMENTAL DATA ; EXPERIMENTAL NEOPLASMS ; Female ; HEAVY NUCLEI ; HOURS LIVING RADIOISOTOPES ; INFORMATION ; ISOTOPES ; LABORATORY ANIMALS ; LET ; Liver ; MAMMALS ; Medical treatment ; MEDICINE ; MICE ; Neoplasm Transplantation ; Neoplasms, Experimental - radiotherapy ; NUCLEAR MEDICINE ; NUCLEI ; NUMERICAL DATA ; ODD-EVEN NUCLEI ; Ovarian Neoplasms ; Pathology ; Phosphates - therapeutic use ; Phosphorus Radioisotopes - therapeutic use ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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James</creatorcontrib><creatorcontrib>Gordon, Phillip R.</creatorcontrib><creatorcontrib>Ruth, Thomas J.</creatorcontrib><creatorcontrib>Wolf, Alfred P.</creatorcontrib><title>Astatine-211--Tellurium Radiocolloid Cures Experimental Malignant Ascites</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>An investigation of the efficacy of astatine-211—tellurium colloid for the treatment of experimental malignant ascites in mice reveals that this α-emitting radiocolloid can be curative without causing undue toxicity to normal tissue. By comparison, negatron-emitting phosphorus-32 as colloidal chromic phosphate had no antineoplastic activity. The most compelling explanation for this striking difference is the dense ionization and short range of action associated with α-emission. These results have important implications for the development and use of α -emitters as radiocolloid therapy for the treatment of human tumors.</description><subject>550603 - Medicine- External Radiation in Therapy- (1980-)</subject><subject>560162 - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells</subject><subject>ALPHA DECAY RADIOISOTOPES</subject><subject>Alpha Particles</subject><subject>ANIMALS</subject><subject>Antineoplastics</subject><subject>Ascites</subject><subject>Ascites - radiotherapy</subject><subject>Astatine</subject><subject>Astatine - therapeutic use</subject><subject>ASTATINE 211</subject><subject>ASTATINE ISOTOPES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>CELL KILLING</subject><subject>Cell Survival - radiation effects</subject><subject>Chromium - therapeutic use</subject><subject>Chromium Compounds</subject><subject>COLLOIDS</subject><subject>DATA</subject><subject>DISPERSIONS</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>EHRLICH ASCITES TUMOR</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>ELEMENTS</subject><subject>ENERGY TRANSFER</subject><subject>EXPERIMENTAL DATA</subject><subject>EXPERIMENTAL NEOPLASMS</subject><subject>Female</subject><subject>HEAVY NUCLEI</subject><subject>HOURS LIVING RADIOISOTOPES</subject><subject>INFORMATION</subject><subject>ISOTOPES</subject><subject>LABORATORY ANIMALS</subject><subject>LET</subject><subject>Liver</subject><subject>MAMMALS</subject><subject>Medical treatment</subject><subject>MEDICINE</subject><subject>MICE</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - radiotherapy</subject><subject>NUCLEAR MEDICINE</subject><subject>NUCLEI</subject><subject>NUMERICAL DATA</subject><subject>ODD-EVEN NUCLEI</subject><subject>Ovarian Neoplasms</subject><subject>Pathology</subject><subject>Phosphates - therapeutic use</subject><subject>Phosphorus Radioisotopes - therapeutic use</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIOCOLLOIDS</subject><subject>RADIOISOTOPES</subject><subject>Radioisotopes - therapeutic use</subject><subject>RADIOLOGY</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOTHERAPY</subject><subject>RBE</subject><subject>RODENTS</subject><subject>SEMIMETALS</subject><subject>SURVIVAL CURVES</subject><subject>SURVIVAL TIME</subject><subject>TELLURIUM</subject><subject>Tellurium - therapeutic use</subject><subject>THERAPY</subject><subject>Transplantation, Homologous</subject><subject>Tumors</subject><subject>VERTEBRATES</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkN1LwzAUxYMoc06ffVEovmfLzVfbxzGmDiaCzOeSpolmdM1oUtD_3mqLe7oXzu_cezgI3QKZA1C5CNqZRpt5SkkuGD9DU-gXnFPCztGUECZxRlJxia5C2BPSazmboMmIT9FmGaKKrjGYAmC8M3Xdta47JG-qcl77uvauSlZda0Ky_jqa1h1ME1WdvKjafTSqicmyzxBNuEYXVtXB3Ixzht4f17vVM96-Pm1Wyy3WnMmIFVdZaWkFubVWV0SBlCAk2NwC5VQBy1JQuRVAhaYll1Tqkok0Kw3XhBE2Qw_DXR-iK_5-60_tm8boWEghiMhkDy0GSLc-hNbY4tgnV-13AaT4La4YiyvGJnrH_eA4duXBVP_8Sb8b9H2Ivj2dk5ngXLIfmK9zEg</recordid><startdate>19810417</startdate><enddate>19810417</enddate><creator>Bloomer, William D.</creator><creator>McLaughlin, William H.</creator><creator>Neirinckx, Rudi D.</creator><creator>Adelstein, S. 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James ; Gordon, Phillip R. ; Ruth, Thomas J. ; Wolf, Alfred P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-a4a8bf2d19fffcd0a1661561f9f1242a13871a9f5125c2b4626cb3578be4c0303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>550603 - Medicine- External Radiation in Therapy- (1980-)</topic><topic>560162 - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells</topic><topic>ALPHA DECAY RADIOISOTOPES</topic><topic>Alpha Particles</topic><topic>ANIMALS</topic><topic>Antineoplastics</topic><topic>Ascites</topic><topic>Ascites - radiotherapy</topic><topic>Astatine</topic><topic>Astatine - therapeutic use</topic><topic>ASTATINE 211</topic><topic>ASTATINE ISOTOPES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>CELL KILLING</topic><topic>Cell Survival - radiation effects</topic><topic>Chromium - therapeutic use</topic><topic>Chromium Compounds</topic><topic>COLLOIDS</topic><topic>DATA</topic><topic>DISPERSIONS</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>EHRLICH ASCITES TUMOR</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>ELEMENTS</topic><topic>ENERGY TRANSFER</topic><topic>EXPERIMENTAL DATA</topic><topic>EXPERIMENTAL NEOPLASMS</topic><topic>Female</topic><topic>HEAVY NUCLEI</topic><topic>HOURS LIVING RADIOISOTOPES</topic><topic>INFORMATION</topic><topic>ISOTOPES</topic><topic>LABORATORY ANIMALS</topic><topic>LET</topic><topic>Liver</topic><topic>MAMMALS</topic><topic>Medical treatment</topic><topic>MEDICINE</topic><topic>MICE</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Experimental - radiotherapy</topic><topic>NUCLEAR MEDICINE</topic><topic>NUCLEI</topic><topic>NUMERICAL DATA</topic><topic>ODD-EVEN NUCLEI</topic><topic>Ovarian Neoplasms</topic><topic>Pathology</topic><topic>Phosphates - therapeutic use</topic><topic>Phosphorus Radioisotopes - therapeutic use</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIOCOLLOIDS</topic><topic>RADIOISOTOPES</topic><topic>Radioisotopes - therapeutic use</topic><topic>RADIOLOGY</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOTHERAPY</topic><topic>RBE</topic><topic>RODENTS</topic><topic>SEMIMETALS</topic><topic>SURVIVAL CURVES</topic><topic>SURVIVAL TIME</topic><topic>TELLURIUM</topic><topic>Tellurium - therapeutic use</topic><topic>THERAPY</topic><topic>Transplantation, Homologous</topic><topic>Tumors</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bloomer, William D.</creatorcontrib><creatorcontrib>McLaughlin, William H.</creatorcontrib><creatorcontrib>Neirinckx, Rudi D.</creatorcontrib><creatorcontrib>Adelstein, S. James</creatorcontrib><creatorcontrib>Gordon, Phillip R.</creatorcontrib><creatorcontrib>Ruth, Thomas J.</creatorcontrib><creatorcontrib>Wolf, Alfred P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bloomer, William D.</au><au>McLaughlin, William H.</au><au>Neirinckx, Rudi D.</au><au>Adelstein, S. James</au><au>Gordon, Phillip R.</au><au>Ruth, Thomas J.</au><au>Wolf, Alfred P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Astatine-211--Tellurium Radiocolloid Cures Experimental Malignant Ascites</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1981-04-17</date><risdate>1981</risdate><volume>212</volume><issue>4492</issue><spage>340</spage><epage>341</epage><pages>340-341</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>An investigation of the efficacy of astatine-211—tellurium colloid for the treatment of experimental malignant ascites in mice reveals that this α-emitting radiocolloid can be curative without causing undue toxicity to normal tissue. By comparison, negatron-emitting phosphorus-32 as colloidal chromic phosphate had no antineoplastic activity. The most compelling explanation for this striking difference is the dense ionization and short range of action associated with α-emission. These results have important implications for the development and use of α -emitters as radiocolloid therapy for the treatment of human tumors.</abstract><cop>United States</cop><pub>The American Association for the Advancement of Science</pub><pmid>7209534</pmid><doi>10.1126/science.7209534</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1981-04, Vol.212 (4492), p.340-341 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_crossref_primary_10_1126_science_7209534 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | 550603 - Medicine- External Radiation in Therapy- (1980-) 560162 - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells ALPHA DECAY RADIOISOTOPES Alpha Particles ANIMALS Antineoplastics Ascites Ascites - radiotherapy Astatine Astatine - therapeutic use ASTATINE 211 ASTATINE ISOTOPES BETA DECAY RADIOISOTOPES CELL KILLING Cell Survival - radiation effects Chromium - therapeutic use Chromium Compounds COLLOIDS DATA DISPERSIONS DOSE-RESPONSE RELATIONSHIPS EHRLICH ASCITES TUMOR ELECTRON CAPTURE RADIOISOTOPES ELEMENTS ENERGY TRANSFER EXPERIMENTAL DATA EXPERIMENTAL NEOPLASMS Female HEAVY NUCLEI HOURS LIVING RADIOISOTOPES INFORMATION ISOTOPES LABORATORY ANIMALS LET Liver MAMMALS Medical treatment MEDICINE MICE Neoplasm Transplantation Neoplasms, Experimental - radiotherapy NUCLEAR MEDICINE NUCLEI NUMERICAL DATA ODD-EVEN NUCLEI Ovarian Neoplasms Pathology Phosphates - therapeutic use Phosphorus Radioisotopes - therapeutic use RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOCOLLOIDS RADIOISOTOPES Radioisotopes - therapeutic use RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY RBE RODENTS SEMIMETALS SURVIVAL CURVES SURVIVAL TIME TELLURIUM Tellurium - therapeutic use THERAPY Transplantation, Homologous Tumors VERTEBRATES |
| title | Astatine-211--Tellurium Radiocolloid Cures Experimental Malignant Ascites |
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