Nonvolatile Mutagens in Drinking Water: Production by Chlorination and Destruction by Sulfite
In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chlorami...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1980-01, Vol.207 (4426), p.90-92 |
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| container_end_page | 92 |
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| container_issue | 4426 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 207 |
| creator | Cheh, Albert M. Skochdopole, Jill Koski, Paul Cole, Larry |
| description | In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents. |
| doi_str_mv | 10.1126/science.6985746 |
| format | Article |
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The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.6985746</identifier><identifier>PMID: 6985746</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>560302 - Chemicals Metabolism & Toxicology- Microorganisms- (-1987) ; AMINES ; Awards ; BENCH-SCALE EXPERIMENTS ; CHALCOGENIDES ; Chemical Phenomena ; CHEMICAL REACTIONS ; Chemistry ; Chloramines ; Chlorination ; Chlorine ; DECHLORINATION ; Dose response relationship ; DRINKING WATER ; HYDROGEN COMPOUNDS ; MUTAGEN SCREENING ; Mutagens ; Mutagens - analysis ; ORGANIC CHLORINE COMPOUNDS ; ORGANIC COMPOUNDS ; ORGANIC HALOGEN COMPOUNDS ; OXIDES ; OXYGEN COMPOUNDS ; Plants ; Potable water ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; Resins ; Salmonella typhimurium - genetics ; SCREENING ; SULFITES ; SULFUR COMPOUNDS ; SULFUR DIOXIDE ; SULFUR OXIDES ; WATER ; Water Pollutants - analysis ; Water Pollutants, Chemical - analysis ; Water Supply - analysis ; Water treatment</subject><ispartof>Science (American Association for the Advancement of Science), 1980-01, Vol.207 (4426), p.90-92</ispartof><rights>Copyright 1979 The American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-1990a9ee4faaa663682a8ac8c82503314f9a3bcbb9df0086519bcdb07fb594353</citedby><cites>FETCH-LOGICAL-c350t-1990a9ee4faaa663682a8ac8c82503314f9a3bcbb9df0086519bcdb07fb594353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1683219$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1683219$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,886,2885,2886,27929,27930,58022,58255</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6985746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5175639$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheh, Albert M.</creatorcontrib><creatorcontrib>Skochdopole, Jill</creatorcontrib><creatorcontrib>Koski, Paul</creatorcontrib><creatorcontrib>Cole, Larry</creatorcontrib><creatorcontrib>Univ of Minnesota</creatorcontrib><title>Nonvolatile Mutagens in Drinking Water: Production by Chlorination and Destruction by Sulfite</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.</description><subject>560302 - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)</subject><subject>AMINES</subject><subject>Awards</subject><subject>BENCH-SCALE EXPERIMENTS</subject><subject>CHALCOGENIDES</subject><subject>Chemical Phenomena</subject><subject>CHEMICAL REACTIONS</subject><subject>Chemistry</subject><subject>Chloramines</subject><subject>Chlorination</subject><subject>Chlorine</subject><subject>DECHLORINATION</subject><subject>Dose response relationship</subject><subject>DRINKING WATER</subject><subject>HYDROGEN COMPOUNDS</subject><subject>MUTAGEN SCREENING</subject><subject>Mutagens</subject><subject>Mutagens - analysis</subject><subject>ORGANIC CHLORINE COMPOUNDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC HALOGEN COMPOUNDS</subject><subject>OXIDES</subject><subject>OXYGEN COMPOUNDS</subject><subject>Plants</subject><subject>Potable water</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>Resins</subject><subject>Salmonella typhimurium - genetics</subject><subject>SCREENING</subject><subject>SULFITES</subject><subject>SULFUR COMPOUNDS</subject><subject>SULFUR DIOXIDE</subject><subject>SULFUR OXIDES</subject><subject>WATER</subject><subject>Water Pollutants - analysis</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water Supply - analysis</subject><subject>Water treatment</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LwzAYxoMoc07PXhSC925J06SNN9n8Ar9AxZOUJE23zC4ZSSrsv7e64k4vL7_f8xweAE4xGmOcsklQRlulx4wXNM_YHhhixGnCU0T2wRAhwpIC5fQQHIWwRKhjnAzAoNeH4PPJ2W_XiGgaDR_bKObaBmgsnHljv4ydww8Rtb-EL95VrYrGWSg3cLpoXCeIv1_YCs50iH7HX9umNlEfg4NaNEGf9HcE3m-u36Z3ycPz7f306iFRhKKYYM6R4FpntRCCMcKKVBRCFapIKSIEZzUXRCopeVUjVDCKuVSVRHktKc8IJSNwse11IZqy2yRqtVDOWq1iSXFOGeGdNNlKyrsQvK7LtTcr4TclRuXvmGU_Ztmv0yXOt4l1K1e6-vd3_GzLlyE6v6tjBUkxJz_PTnvP</recordid><startdate>19800104</startdate><enddate>19800104</enddate><creator>Cheh, Albert M.</creator><creator>Skochdopole, Jill</creator><creator>Koski, Paul</creator><creator>Cole, Larry</creator><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19800104</creationdate><title>Nonvolatile Mutagens in Drinking Water: Production by Chlorination and Destruction by Sulfite</title><author>Cheh, Albert M. ; Skochdopole, Jill ; Koski, Paul ; Cole, Larry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-1990a9ee4faaa663682a8ac8c82503314f9a3bcbb9df0086519bcdb07fb594353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>560302 - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)</topic><topic>AMINES</topic><topic>Awards</topic><topic>BENCH-SCALE EXPERIMENTS</topic><topic>CHALCOGENIDES</topic><topic>Chemical Phenomena</topic><topic>CHEMICAL REACTIONS</topic><topic>Chemistry</topic><topic>Chloramines</topic><topic>Chlorination</topic><topic>Chlorine</topic><topic>DECHLORINATION</topic><topic>Dose response relationship</topic><topic>DRINKING WATER</topic><topic>HYDROGEN COMPOUNDS</topic><topic>MUTAGEN SCREENING</topic><topic>Mutagens</topic><topic>Mutagens - analysis</topic><topic>ORGANIC CHLORINE COMPOUNDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC HALOGEN COMPOUNDS</topic><topic>OXIDES</topic><topic>OXYGEN COMPOUNDS</topic><topic>Plants</topic><topic>Potable water</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>Resins</topic><topic>Salmonella typhimurium - genetics</topic><topic>SCREENING</topic><topic>SULFITES</topic><topic>SULFUR COMPOUNDS</topic><topic>SULFUR DIOXIDE</topic><topic>SULFUR OXIDES</topic><topic>WATER</topic><topic>Water Pollutants - analysis</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Water Supply - analysis</topic><topic>Water treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheh, Albert M.</creatorcontrib><creatorcontrib>Skochdopole, Jill</creatorcontrib><creatorcontrib>Koski, Paul</creatorcontrib><creatorcontrib>Cole, Larry</creatorcontrib><creatorcontrib>Univ of Minnesota</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheh, Albert M.</au><au>Skochdopole, Jill</au><au>Koski, Paul</au><au>Cole, Larry</au><aucorp>Univ of Minnesota</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonvolatile Mutagens in Drinking Water: Production by Chlorination and Destruction by Sulfite</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1980-01-04</date><risdate>1980</risdate><volume>207</volume><issue>4426</issue><spage>90</spage><epage>92</epage><pages>90-92</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.</abstract><cop>United States</cop><pub>The American Association for the Advancement of Science</pub><pmid>6985746</pmid><doi>10.1126/science.6985746</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1980-01, Vol.207 (4426), p.90-92 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_crossref_primary_10_1126_science_6985746 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | 560302 - Chemicals Metabolism & Toxicology- Microorganisms- (-1987) AMINES Awards BENCH-SCALE EXPERIMENTS CHALCOGENIDES Chemical Phenomena CHEMICAL REACTIONS Chemistry Chloramines Chlorination Chlorine DECHLORINATION Dose response relationship DRINKING WATER HYDROGEN COMPOUNDS MUTAGEN SCREENING Mutagens Mutagens - analysis ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS OXIDES OXYGEN COMPOUNDS Plants Potable water RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Resins Salmonella typhimurium - genetics SCREENING SULFITES SULFUR COMPOUNDS SULFUR DIOXIDE SULFUR OXIDES WATER Water Pollutants - analysis Water Pollutants, Chemical - analysis Water Supply - analysis Water treatment |
| title | Nonvolatile Mutagens in Drinking Water: Production by Chlorination and Destruction by Sulfite |
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