Kepone-Induced Scoliosis and Its Histological Consequences in Fish
Scoliosis in fish is caused by several diverse agents that possibly act on the central nervous system, neuromuscular junctions, or ionic metabolism. The organochlorine pesticide Kepone induces scoliosis in the sheepshead minnow. Some effects associated with Kepone-induced scoliosis in these fish are...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1977-08, Vol.197 (4303), p.585-587 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 587 |
|---|---|
| container_issue | 4303 |
| container_start_page | 585 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 197 |
| creator | Couch, John A. Winstead, James T. Goodman, Larry R. |
| description | Scoliosis in fish is caused by several diverse agents that possibly act on the central nervous system, neuromuscular junctions, or ionic metabolism. The organochlorine pesticide Kepone induces scoliosis in the sheepshead minnow. Some effects associated with Kepone-induced scoliosis in these fish are disruption of myotomal patterns, inter- and intramuscular hemorrhage, fractured centra of vertebrae, and death. The histological syndrome of Kepone poisoning in fish and the clinical syndrome in humans suggest that the nervous system is a primary target for Kepone and that scoliosis is a secondary effect of Kepone poisoning in fish. |
| doi_str_mv | 10.1126/science.69318 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1126_science_69318</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>1745076</jstor_id><sourcerecordid>1745076</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-57f459c67e47719988deb92a4814e25852b5ab440e6b9ee39ead4c7462b3262a3</originalsourceid><addsrcrecordid>eNpFkLtOAzEQRS1EBCFQUkHhH3Dw2-sSIkIiIlEA9crrnYCjzTrsJAV_T15ANcU5uqN7CbkWfCiEtHcYE7QRhtYrUZyQvuDeMC-5OiV9zpVlBXfmnFwgLjjfMq_OSG8v98nDM6xyC2za1psINX2NuUkZE9LQ1nS6RjpJuM5N_kgxNHSUW4Svze4d0tTSccLPS9Kbhwbh6ngH5H38-DaasNnL03R0P2NRKbdmxs218dE60M4J74uihsrLoAuhQZrCyMqESmsOtvIAykOodXTaykpJK4MaEHbIjV1G7GBerrq0DN13KXi5G6I8DlHuu239m4O_2lRLqP_sX3p7oIttve4_ymnDnVU_wm9jJA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Kepone-Induced Scoliosis and Its Histological Consequences in Fish</title><source>American Association for the Advancement of Science</source><source>Jstor Complete Legacy</source><source>MEDLINE</source><creator>Couch, John A. ; Winstead, James T. ; Goodman, Larry R.</creator><creatorcontrib>Couch, John A. ; Winstead, James T. ; Goodman, Larry R.</creatorcontrib><description>Scoliosis in fish is caused by several diverse agents that possibly act on the central nervous system, neuromuscular junctions, or ionic metabolism. The organochlorine pesticide Kepone induces scoliosis in the sheepshead minnow. Some effects associated with Kepone-induced scoliosis in these fish are disruption of myotomal patterns, inter- and intramuscular hemorrhage, fractured centra of vertebrae, and death. The histological syndrome of Kepone poisoning in fish and the clinical syndrome in humans suggest that the nervous system is a primary target for Kepone and that scoliosis is a secondary effect of Kepone poisoning in fish.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.69318</identifier><identifier>PMID: 69318</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animals ; Calcium - metabolism ; Chlordecone - poisoning ; Dose-Response Relationship, Drug ; Fish Diseases - chemically induced ; Fishes ; Hemorrhage - pathology ; Histology ; Insecticides - poisoning ; Lesions ; Muscle Contraction ; Muscles - pathology ; Poisoning ; Scoliosis ; Scoliosis - chemically induced ; Scoliosis - pathology ; Scoliosis - veterinary ; Sea water ; Spinal fractures ; Spine ; Spine - pathology ; Time Factors ; Vertebrae</subject><ispartof>Science (American Association for the Advancement of Science), 1977-08, Vol.197 (4303), p.585-587</ispartof><rights>Copyright 1977 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-57f459c67e47719988deb92a4814e25852b5ab440e6b9ee39ead4c7462b3262a3</citedby><cites>FETCH-LOGICAL-c337t-57f459c67e47719988deb92a4814e25852b5ab440e6b9ee39ead4c7462b3262a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1745076$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1745076$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/69318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Couch, John A.</creatorcontrib><creatorcontrib>Winstead, James T.</creatorcontrib><creatorcontrib>Goodman, Larry R.</creatorcontrib><title>Kepone-Induced Scoliosis and Its Histological Consequences in Fish</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Scoliosis in fish is caused by several diverse agents that possibly act on the central nervous system, neuromuscular junctions, or ionic metabolism. The organochlorine pesticide Kepone induces scoliosis in the sheepshead minnow. Some effects associated with Kepone-induced scoliosis in these fish are disruption of myotomal patterns, inter- and intramuscular hemorrhage, fractured centra of vertebrae, and death. The histological syndrome of Kepone poisoning in fish and the clinical syndrome in humans suggest that the nervous system is a primary target for Kepone and that scoliosis is a secondary effect of Kepone poisoning in fish.</description><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Chlordecone - poisoning</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fish Diseases - chemically induced</subject><subject>Fishes</subject><subject>Hemorrhage - pathology</subject><subject>Histology</subject><subject>Insecticides - poisoning</subject><subject>Lesions</subject><subject>Muscle Contraction</subject><subject>Muscles - pathology</subject><subject>Poisoning</subject><subject>Scoliosis</subject><subject>Scoliosis - chemically induced</subject><subject>Scoliosis - pathology</subject><subject>Scoliosis - veterinary</subject><subject>Sea water</subject><subject>Spinal fractures</subject><subject>Spine</subject><subject>Spine - pathology</subject><subject>Time Factors</subject><subject>Vertebrae</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkLtOAzEQRS1EBCFQUkHhH3Dw2-sSIkIiIlEA9crrnYCjzTrsJAV_T15ANcU5uqN7CbkWfCiEtHcYE7QRhtYrUZyQvuDeMC-5OiV9zpVlBXfmnFwgLjjfMq_OSG8v98nDM6xyC2za1psINX2NuUkZE9LQ1nS6RjpJuM5N_kgxNHSUW4Svze4d0tTSccLPS9Kbhwbh6ngH5H38-DaasNnL03R0P2NRKbdmxs218dE60M4J74uihsrLoAuhQZrCyMqESmsOtvIAykOodXTaykpJK4MaEHbIjV1G7GBerrq0DN13KXi5G6I8DlHuu239m4O_2lRLqP_sX3p7oIttve4_ymnDnVU_wm9jJA</recordid><startdate>19770805</startdate><enddate>19770805</enddate><creator>Couch, John A.</creator><creator>Winstead, James T.</creator><creator>Goodman, Larry R.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19770805</creationdate><title>Kepone-Induced Scoliosis and Its Histological Consequences in Fish</title><author>Couch, John A. ; Winstead, James T. ; Goodman, Larry R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-57f459c67e47719988deb92a4814e25852b5ab440e6b9ee39ead4c7462b3262a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Calcium - metabolism</topic><topic>Chlordecone - poisoning</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fish Diseases - chemically induced</topic><topic>Fishes</topic><topic>Hemorrhage - pathology</topic><topic>Histology</topic><topic>Insecticides - poisoning</topic><topic>Lesions</topic><topic>Muscle Contraction</topic><topic>Muscles - pathology</topic><topic>Poisoning</topic><topic>Scoliosis</topic><topic>Scoliosis - chemically induced</topic><topic>Scoliosis - pathology</topic><topic>Scoliosis - veterinary</topic><topic>Sea water</topic><topic>Spinal fractures</topic><topic>Spine</topic><topic>Spine - pathology</topic><topic>Time Factors</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Couch, John A.</creatorcontrib><creatorcontrib>Winstead, James T.</creatorcontrib><creatorcontrib>Goodman, Larry R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Couch, John A.</au><au>Winstead, James T.</au><au>Goodman, Larry R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kepone-Induced Scoliosis and Its Histological Consequences in Fish</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1977-08-05</date><risdate>1977</risdate><volume>197</volume><issue>4303</issue><spage>585</spage><epage>587</epage><pages>585-587</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Scoliosis in fish is caused by several diverse agents that possibly act on the central nervous system, neuromuscular junctions, or ionic metabolism. The organochlorine pesticide Kepone induces scoliosis in the sheepshead minnow. Some effects associated with Kepone-induced scoliosis in these fish are disruption of myotomal patterns, inter- and intramuscular hemorrhage, fractured centra of vertebrae, and death. The histological syndrome of Kepone poisoning in fish and the clinical syndrome in humans suggest that the nervous system is a primary target for Kepone and that scoliosis is a secondary effect of Kepone poisoning in fish.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>69318</pmid><doi>10.1126/science.69318</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1977-08, Vol.197 (4303), p.585-587 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_crossref_primary_10_1126_science_69318 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animals Calcium - metabolism Chlordecone - poisoning Dose-Response Relationship, Drug Fish Diseases - chemically induced Fishes Hemorrhage - pathology Histology Insecticides - poisoning Lesions Muscle Contraction Muscles - pathology Poisoning Scoliosis Scoliosis - chemically induced Scoliosis - pathology Scoliosis - veterinary Sea water Spinal fractures Spine Spine - pathology Time Factors Vertebrae |
| title | Kepone-Induced Scoliosis and Its Histological Consequences in Fish |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T16%3A28%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Kepone-Induced%20Scoliosis%20and%20Its%20Histological%20Consequences%20in%20Fish&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Couch,%20John%20A.&rft.date=1977-08-05&rft.volume=197&rft.issue=4303&rft.spage=585&rft.epage=587&rft.pages=585-587&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.69318&rft_dat=%3Cjstor_cross%3E1745076%3C/jstor_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/69318&rft_jstor_id=1745076&rfr_iscdi=true |