Hepatocarcinogenicity of glandless cottonseeds and cottonseed oil to rainbow trout (Salmo gairdnerii) [Food toxicity aspects]

Glandless cottonseed kernels are available for purchase and consumption by the general public. These kernels contain no gossypol but still have a full complement of naturally occurring cyclopropenoid fatty acids, which in rainbow trout are active as synergists with aflatoxins and primary liver carci...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1980-04, Vol.208 (4441), p.309-311
Hauptverfasser:	Hendricks, J. D., Sinnhuber, R. O., Loveland, P. M., Pawlowski, N. E., Nixon, J. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflatoxins Animal Feed - adverse effects Animals Carcinogens Cottonseed Oil Cyclopropanes Diet Drug Synergism Fatty acids Fatty Acids, Monounsaturated Fatty Acids, Unsaturated Fish feeding Lipids Liver Liver cancer Liver Neoplasms, Experimental - chemically induced Trout Tumors
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container_end_page	311
container_issue	4441
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container_title	Science (American Association for the Advancement of Science)
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creator	Hendricks, J. D. Sinnhuber, R. O. Loveland, P. M. Pawlowski, N. E. Nixon, J. E.
description	Glandless cottonseed kernels are available for purchase and consumption by the general public. These kernels contain no gossypol but still have a full complement of naturally occurring cyclopropenoid fatty acids, which in rainbow trout are active as synergists with aflatoxins and primary liver carcinogens. Diets containing glandless cottonseed kernels or a lightly processed cottonseed oil produced significant numbers of hepatocellular carcinomas in rainbow trout after 1 year. The much greater incidence of cancer induced by the kernel than by the oil indicates that synergists or other carcinogens may be present in the kernel in addition to the cyclopropenoid fatty acids.
doi_str_mv	10.1126/science.6892734
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The much greater incidence of cancer induced by the kernel than by the oil indicates that synergists or other carcinogens may be present in the kernel in addition to the cyclopropenoid fatty acids.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.6892734</identifier><identifier>PMID: 6892734</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Aflatoxins ; Animal Feed - adverse effects ; Animals ; Carcinogens ; Cottonseed Oil ; Cyclopropanes ; Diet ; Drug Synergism ; Fatty acids ; Fatty Acids, Monounsaturated ; Fatty Acids, Unsaturated ; Fish feeding ; Lipids ; Liver ; Liver cancer ; Liver Neoplasms, Experimental - chemically induced ; Trout ; Tumors</subject><ispartof>Science (American Association for the Advancement of Science), 1980-04, Vol.208 (4441), p.309-311</ispartof><rights>Copyright 1980 The American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-6cdeea8486d26b3917c27859aba91f1cb974fb561a2a9b4d2748132ab41862583</citedby><cites>FETCH-LOGICAL-c366t-6cdeea8486d26b3917c27859aba91f1cb974fb561a2a9b4d2748132ab41862583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1683255$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1683255$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6892734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hendricks, J. 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The much greater incidence of cancer induced by the kernel than by the oil indicates that synergists or other carcinogens may be present in the kernel in addition to the cyclopropenoid fatty acids.</description><subject>Aflatoxins</subject><subject>Animal Feed - adverse effects</subject><subject>Animals</subject><subject>Carcinogens</subject><subject>Cottonseed Oil</subject><subject>Cyclopropanes</subject><subject>Diet</subject><subject>Drug Synergism</subject><subject>Fatty acids</subject><subject>Fatty Acids, Monounsaturated</subject><subject>Fatty Acids, Unsaturated</subject><subject>Fish feeding</subject><subject>Lipids</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver Neoplasms, Experimental - chemically induced</subject><subject>Trout</subject><subject>Tumors</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkL1PwzAUxC0EKuVjZgHkEYZQfySOPSJEKRISQ-mEUPTiOJWrNK5sV9CB_52gRJTp6d7v7oZD6IKSO0qZmARtTavNnZCK5Tw9QGNKVJYoRvghGhPCRSJJnh2jkxBWhHRM8REaDfYx-p6ZDUSnwWvbuqVprbZxh12Nlw20VWNCwNrF6NpgTBVw9_unsbMNjg57sG3pPnH0bhvxzRyatcNLsL5qjbf2Fr9Pnas651dfD2FjdAwfZ-iohiaY8-GeosX08e1hlry8Pj0_3L8kmgsRE6ErY0CmUlRMlFzRXLNcZgpKULSmulR5WpeZoMBAlWnF8lRSzqBMqRQsk_wUTfpe7V0I3tTFxts1-F1BSfG7YzHsWAzDdImrPrHZlmtT_fn3_LLnqxCd39cJyVmWdfi6xzW4ApbehmIxp0pSIoSQVPAf_NCFHw</recordid><startdate>19800418</startdate><enddate>19800418</enddate><creator>Hendricks, J. 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E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-6cdeea8486d26b3917c27859aba91f1cb974fb561a2a9b4d2748132ab41862583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Aflatoxins</topic><topic>Animal Feed - adverse effects</topic><topic>Animals</topic><topic>Carcinogens</topic><topic>Cottonseed Oil</topic><topic>Cyclopropanes</topic><topic>Diet</topic><topic>Drug Synergism</topic><topic>Fatty acids</topic><topic>Fatty Acids, Monounsaturated</topic><topic>Fatty Acids, Unsaturated</topic><topic>Fish feeding</topic><topic>Lipids</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver Neoplasms, Experimental - chemically induced</topic><topic>Trout</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hendricks, J. D.</creatorcontrib><creatorcontrib>Sinnhuber, R. O.</creatorcontrib><creatorcontrib>Loveland, P. M.</creatorcontrib><creatorcontrib>Pawlowski, N. E.</creatorcontrib><creatorcontrib>Nixon, J. E.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hendricks, J. D.</au><au>Sinnhuber, R. O.</au><au>Loveland, P. M.</au><au>Pawlowski, N. E.</au><au>Nixon, J. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatocarcinogenicity of glandless cottonseeds and cottonseed oil to rainbow trout (Salmo gairdnerii) [Food toxicity aspects]</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1980-04-18</date><risdate>1980</risdate><volume>208</volume><issue>4441</issue><spage>309</spage><epage>311</epage><pages>309-311</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Glandless cottonseed kernels are available for purchase and consumption by the general public. These kernels contain no gossypol but still have a full complement of naturally occurring cyclopropenoid fatty acids, which in rainbow trout are active as synergists with aflatoxins and primary liver carcinogens. Diets containing glandless cottonseed kernels or a lightly processed cottonseed oil produced significant numbers of hepatocellular carcinomas in rainbow trout after 1 year. The much greater incidence of cancer induced by the kernel than by the oil indicates that synergists or other carcinogens may be present in the kernel in addition to the cyclopropenoid fatty acids.</abstract><cop>United States</cop><pub>The American Association for the Advancement of Science</pub><pmid>6892734</pmid><doi>10.1126/science.6892734</doi><tpages>3</tpages></addata></record>
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source	American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE
subjects	Aflatoxins Animal Feed - adverse effects Animals Carcinogens Cottonseed Oil Cyclopropanes Diet Drug Synergism Fatty acids Fatty Acids, Monounsaturated Fatty Acids, Unsaturated Fish feeding Lipids Liver Liver cancer Liver Neoplasms, Experimental - chemically induced Trout Tumors
title	Hepatocarcinogenicity of glandless cottonseeds and cottonseed oil to rainbow trout (Salmo gairdnerii) [Food toxicity aspects]
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