Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways

The circadian clock temporally coordinates metabolic homeostasis in mammals. Central to this is heme, an iron-containing porphyrin that serves as prosthetic group for enzymes involved in oxidative metabolism as well as transcription factors that regulate circadian rhythmicity. The circadian factor t...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2007-12, Vol.318 (5857), p.1786-1789
Hauptverfasser:	Yin, Lei, Wu, Nan, Curtin, Joshua C, Qatanani, Mohammed, Szwergold, Nava R, Reid, Robert A, Waitt, Gregory M, Parks, Derek J, Pearce, Kenneth H, Wisely, G. Bruce, Lazar, Mitchell A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chronobiology Co repressor proteins Energy metabolism Fundamental and applied biological sciences. Psychology Genes HeLa cells Hep G2 cells Lipid metabolism Liver cells Repression rev genes Small interfering RNA Vertebrates: anatomy and physiology, studies on body, several organs or systems
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