Structure of Gαq-p63RhoGEF-RhoA Complex Reveals a Pathway for the Activation of RhoA by GPCRs

The guanine nucleotide exchange factor p63RhoGEF is an effector of the heterotrimeric guanine nucleotide-binding protein (G protein) Gαq and thereby links Gαq-coupled receptors (GPCRs) to the activation of the small-molecular-weight G protein RhoA. We determined the crystal structure of the Gαq-p63R...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2007-12, Vol.318 (5858), p.1923-1927
Hauptverfasser:	Lutz, Susanne, Shankaranarayanan, Aruna, Coco, Cassandra, Ridilla, Marc, Nance, Mark R, Vettel, Christiane, Baltus, Doris, Evelyn, Chris R, Neubig, Richard R, Wieland, Thomas, Tesmer, John J.G
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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