Negative Regulation of Toll-Like Receptor Signaling by NF-κB p50 Ubiquitination Blockade

Toll-like receptors (TLRs) trigger the production of inflammatory cytokines and shape adaptive and innate immunity to pathogens. We report the identification of B cell leukemia (Bcl)-3 as an essential negative regulator of TLR signaling. By blocking ubiquitination of p50, a member of the nuclear fac...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2007-08, Vol.317 (5838), p.675-678
Hauptverfasser:	Carmody, Ruaidhrí J, Ruan, Qingguo, Palmer, Scott, Hilliard, Brendan, Chen, Youhai H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies B lymphocytes Biological and medical sciences Cytokines Dendritic cells Dimers DNA Fundamental and applied biological sciences. Psychology Fundamental immunology Genetics of the immune response Half lives Immunobiology Macrophages Myeloid cells Pretreatment
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