Prostaglandin E 2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells

The gut microbiota fundamentally regulates intestinal homeostasis and disease partially through mechanisms that involve modulation of regulatory T cells (T ), yet how the microbiota-T cross-talk is physiologically controlled is incompletely defined. Here, we report that prostaglandin E (PGE ), a wel...

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Veröffentlicht in:	Science advances 2021-02, Vol.7 (7)
Hauptverfasser:	Crittenden, Siobhan, Goepp, Marie, Pollock, Jolinda, Robb, Calum T, Smyth, Danielle J, Zhou, You, Andrews, Robert, Tyrrell, Victoria, Gkikas, Konstantinos, Adima, Alexander, O'Connor, Richard A, Davies, Luke, Li, Xue-Feng, Yao, Hatti X, Ho, Gwo-Tzer, Zheng, Xiaozhong, Mair, Amil, Vermeren, Sonja, Qian, Bin-Zhi, Mole, Damian J, Gerasimidis, Konstantinos, Schwarze, Jürgen K J, Breyer, Richard M, Arends, Mark J, O'Donnell, Valerie B, Iredale, John P, Anderton, Stephen M, Narumiya, Shuh, Maizels, Rick M, Rossi, Adriano G, Howie, Sarah E, Yao, Chengcan
Format:	Artikel
Sprache:	eng
Schlagworte:	Dinoprostone - pharmacology Gastrointestinal Microbiome Humans Inflammation Receptors, Prostaglandin E, EP2 Subtype T-Lymphocytes, Regulatory
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