UPR ER promotes lipophagy independent of chaperones to extend life span

Longevity is dictated by a combination of environmental and genetic factors. One of the key mechanisms to regulate life-span extension is the induction of protein chaperones for protein homeostasis. Ectopic activation of the unfolded protein response of the endoplasmic reticulum (UPR ) specifically...

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Veröffentlicht in:	Science advances 2020-01, Vol.6 (1), p.eaaz1441
Hauptverfasser:	Daniele, Joseph R, Higuchi-Sanabria, Ryo, Durieux, Jenni, Monshietehadi, Samira, Ramachandran, Vidhya, Tronnes, Sarah U, Kelet, Naame, Sanchez, Melissa, Metcalf, Melissa G, Garcia, Gilberto, Frankino, Phillip A, Benitez, Camila, Zeng, Mandy, Esping, Daniel J, Joe, Larry, Dillin, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy - genetics Caenorhabditis elegans Caenorhabditis elegans Proteins - genetics Endoplasmic Reticulum - genetics Endoplasmic Reticulum Stress - genetics Humans Lipids - genetics Longevity - genetics Molecular Chaperones - genetics Neurons - metabolism Signal Transduction - genetics Unfolded Protein Response - genetics Vesicular Transport Proteins - genetics
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