G Protein Preassembly Rescues Efficacy of W 6.48 Toggle Mutations in Neuropeptide Y 2 Receptor

Ligand binding and pathway-specific activation of G protein-coupled receptors is currently being studied with great effort. Individual answers may depend on the nature of the ligands and the effector pathway. Recently, we have presented a detailed model of neuropeptide Y bound to the Y R. Accordingl...

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Veröffentlicht in:	Molecular pharmacology 2018-04, Vol.93 (4), p.387-401
Hauptverfasser:	Kaiser, Anette, Hempel, Caroline, Wanka, Lizzy, Schubert, Mario, Hamm, Heidi E, Beck-Sickinger, Annette G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites - physiology Dose-Response Relationship, Drug GTP-Binding Proteins - chemistry GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism HEK293 Cells Humans Mutation - genetics Neuropeptide Y - chemistry Neuropeptide Y - genetics Neuropeptide Y - metabolism Protein Structure, Secondary Receptors, Neuropeptide Y - chemistry Receptors, Neuropeptide Y - genetics Receptors, Neuropeptide Y - metabolism
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