Biochemical Pharmacology of the Sigma-1 Receptor

The sigma-1 receptor (S1R) is a 223 amino acid two transmembrane (TM) pass protein. It is a non-ATP-binding nonglycosylated ligand-regulated molecular chaperone of unknown three-dimensional structure. The S1R is resident to eukaryotic mitochondrial-associated endoplasmic reticulum and plasma membran...

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Veröffentlicht in:	Molecular pharmacology 2016-01, Vol.89 (1), p.142-153
Hauptverfasser:	Chu, Uyen B., Ruoho, Arnold E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analgesics, Opioid - chemistry Analgesics, Opioid - metabolism Analgesics, Opioid - pharmacology Animals Cell Membrane - drug effects Cell Membrane - genetics Cell Membrane - metabolism Humans Molecular Sequence Data Protein Binding - physiology Receptors, sigma - agonists Receptors, sigma - genetics Receptors, sigma - metabolism Sigma-1 Receptor
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