Resveratrol Protects Mitochondria against Oxidative Stress through AMP-Activated Protein Kinase-Mediated Glycogen Synthase Kinase-3β Inhibition Downstream of Poly(ADP-ribose)polymerase-LKB1 Pathway

Arachidonic acid (AA, a proinflammatory fatty acid) in combination with iron promotes excess reactive oxygen species (ROS) production and exerts a deleterious effect on mitochondria. We have shown previously that activation of AMP-activated protein kinase (AMPK) protects hepatocytes from AA + iron-i...

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Veröffentlicht in:	Molecular pharmacology 2009-10, Vol.76 (4), p.884-895
Hauptverfasser:	Shin, Sang Mi, Cho, Il Je, Kim, Sang Geon
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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