Inhibition of Vascular Endothelial Growth Factor Cotranslational Translocation by the Cyclopeptolide CAM741

The cyclopeptolide CAM741 inhibits cotranslational translocation of vascular cell adhesion molecule 1 (VCAM1), which is dependent on its signal peptide. We now describe the identification of the signal peptide of vascular endothelial growth factor (VEGF) as the second target of CAM741. The mechanism...

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Veröffentlicht in:	Molecular pharmacology 2007-06, Vol.71 (6), p.1657-1665
Hauptverfasser:	Harant, Hanna, Wolff, Barbara, Schreiner, Erwin P., Oberhauser, Berndt, Hofer, Lotte, Lettner, Nicole, Maier, Sabine, de Vries, Jan E., Lindley, Ivan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Calcium-Binding Proteins - metabolism Cells, Cultured Humans Membrane Glycoproteins - metabolism Molecular Sequence Data Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Protein Sorting Signals - drug effects Protein Sorting Signals - physiology Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Peptide - metabolism Translocation, Genetic - drug effects Translocation, Genetic - physiology Vascular Cell Adhesion Molecule-1 - metabolism Vascular Endothelial Growth Factor A - metabolism
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