Experimental and Modeling Studies of Desensitization of P2X3 Receptors

The function of ATP-activated P2X3 receptors involved in pain sensation is modulated by desensitization, a phenomenon poorly understood. The present study used patch-clamp recording from cultured rat or mouse sensory neurons and kinetic modeling to clarify the properties of P2X3 receptor desensitiza...

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Veröffentlicht in:	Molecular pharmacology 2006-07, Vol.70 (1), p.373-382
Hauptverfasser:	Sokolova, Elena, Skorinkin, Andrei, Moiseev, Igor, Agrachev, Andrei, Nistri, Andrea, Giniatullin, Rashid
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Animals Cells, Cultured Dose-Response Relationship, Drug Ganglia, Spinal - cytology Ganglia, Spinal - drug effects Ganglia, Spinal - physiology Humans Kinetics Membrane Potentials - drug effects Mice Models, Biological Neurons - drug effects Neurons - metabolism Neurons - physiology Patch-Clamp Techniques Purinergic P2 Receptor Agonists Rats Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - physiology Receptors, Purinergic P2X3 Thionucleotides - pharmacology
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