2-Cyano-3,12-dioxooleana-1,9(11)-diene-28-oic Acid Disrupts Microtubule Polymerization: A Possible Mechanism Contributing to Apoptosis

The semisynthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) has several biological activities, including the induction of apoptosis in many cancer cell lines. To identify potential protein targets, immobilized biotinylated CDDO was used to screen the proteome of a human l...

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Veröffentlicht in:	Molecular pharmacology 2006-04, Vol.69 (4), p.1158-1165
Hauptverfasser:	Couch, Robin D, Ganem, Neil J, Zhou, Ming, Popov, Veljko M, Honda, Tadashi, Veenstra, Timothy D, Sporn, Michael B, Anderson, Amy C
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biopolymers Microscopy, Fluorescence Microtubules - drug effects Microtubules - metabolism Mitosis Oleanolic Acid - analogs & derivatives Oleanolic Acid - pharmacology Tubulin - metabolism
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