Distinct Uptake Kinetics of Alzheimer Disease Amyloid-β 40 and 42 at the Blood-Brain Barrier Endothelium

Blood-brain barrier (BBB) endothelial cells lining the cerebral microvasculature maintain dynamic equilibrium between soluble amyloid-β (Aβ) levels in the brain and plasma. The BBB dysfunction prevalent in Alzheimer disease contributes to the dysregulation of plasma and brain Aβ and leads to the per...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2021-03, Vol.376 (3), p.482-490
Hauptverfasser:	Sharda, Nidhi, Ahlschwede, Kristen M., Curran, Geoffry L., Lowe, Val J., Kandimalla, Karunya K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - metabolism Blood-Brain Barrier - metabolism Cell Line Endothelium - metabolism Humans Kinetics Models, Biological Peptide Fragments - metabolism Protein Transport
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